The role of early life stress as a predictor for alcohol and drug dependence
MA Enoch - Psychopharmacology, 2011 - Springer
Rationale Genetic and environmental influences on the development of alcohol and drug
dependence are equally important. Exposure to early life stress, that is unfortunately …
dependence are equally important. Exposure to early life stress, that is unfortunately …
The influence of gene–environment interactions on the development of alcoholism and drug dependence
MA Enoch - Current psychiatry reports, 2012 - Springer
Alcoholism and drug dependence are common psychiatric disorders with a heritability of
about 50%; therefore genetic and environmental influences are equally important. Early-life …
about 50%; therefore genetic and environmental influences are equally important. Early-life …
A P2X7 receptor antagonist reverses behavioural alterations, microglial activation and neuroendocrine dysregulation in an unpredictable chronic mild stress (UCMS) …
A polymorphism in the P2RX7 gene that encodes for the P2X7 ionotropic ATP-gated
receptor (P2X7R) protein has been shown to be associated with an increased risk for …
receptor (P2X7R) protein has been shown to be associated with an increased risk for …
Stress and the neuroendocrinology of anxiety disorders
Stress is a risk factor for depressive and anxiety disorders. Changes in lifestyle patterns that
are associated with increased stress therefore place a greater burden on mental health …
are associated with increased stress therefore place a greater burden on mental health …
Type of early life adversity confers differential, sex-dependent effects on early maturational milestones in mice
Early life adversity (ELA) increases risk for negative health outcomes, with sex disparities in
prevalence and form of ELA experienced and risk for neuropsychiatric pathology. ELA …
prevalence and form of ELA experienced and risk for neuropsychiatric pathology. ELA …
[HTML][HTML] The behavioral and immunological impact of maternal separation: a matter of timing
Maternal separation (MS), an early life stressful event, has been demonstrated to trigger
neuropsychiatric disorders later in life, in particular depression. Experiments using rodents …
neuropsychiatric disorders later in life, in particular depression. Experiments using rodents …
The development of spatial and memory circuits in the rat
We provide a concise review of recent studies related to the development of neural circuits
supporting spatial navigation and memory in the rat. We chart the relative timeline of the …
supporting spatial navigation and memory in the rat. We chart the relative timeline of the …
Potential programming of dopaminergic circuits by early life stress
Stress and high levels of glucocorticoids during pre-and early postnatal life seem to alter
developmental programs that assure dopaminergic transmission in the mesolimbic …
developmental programs that assure dopaminergic transmission in the mesolimbic …
Protective responses of older adults for avoiding injury during falls: evidence from video capture of real-life falls in long-term care
Background falls are common in older adults, and any fall from standing height onto a rigid
surface has the potential to cause a serious brain injury or bone fracture. Safe strategies for …
surface has the potential to cause a serious brain injury or bone fracture. Safe strategies for …
Stress and glucocorticoid footprints in the brain—the path from depression to Alzheimer's disease
I Sotiropoulos, JJ Cerqueira, C Catania… - Neuroscience & …, 2008 - Elsevier
Increasingly, stress is recognized as a trigger of depressive episodes and recent evidence
suggests a causal role of stress in the onset and progression of Alzheimer's disease (AD) …
suggests a causal role of stress in the onset and progression of Alzheimer's disease (AD) …