Age‐related changes in mitochondria are associated with decline in mitochondrial function.
With advanced age, mitochondrial DNA volume, integrity and functionality decrease due to …

Perturbation of mitochondrial DNA (mtDNA) gene expression can lead to human
pathologies. Therefore, a greater appreciation of the basic mechanisms of mitochondrial …

Mitochondria, which play central roles in immunometabolic diseases, have their own
genome. However, the functions of mitochondria-located noncoding RNAs are largely …

Expression of human mitochondrial DNA is indispensable for proper function of the oxidative
phosphorylation machinery. The mitochondrial genome encodes 22 tRNAs, 2 rRNAs and 11 …

Summary mRNAs continually change their protein partners throughout their lifetimes, yet our
understanding of mRNA-protein complex (mRNP) remodeling is limited by a lack of temporal …

Identifying the genetic basis for mitochondrial diseases is technically challenging given the
size of the mitochondrial proteome and the heterogeneity of disease presentations. Using …

Mitochondria are peculiar organelles whose proper function depends on the crosstalk
between two genomes, mitochondrial and nuclear. The human mitochondrial genome …

Deficiencies in respiratory-chain complexes lead to a variety of clinical phenotypes resulting
from inadequate energy production by the mitochondrial oxidative phosphorylation system …

Human mitochondria contain a genome (mtDNA) that encodes essential subunits of the
oxidative phosphorylation system. Expression of mtDNA entails multi-step maturation of …

Mitochondrial respiratory chain deficiencies exhibit a wide spectrum of clinical presentations
owing to defective mitochondrial energy production through oxidative phosphorylation …