Nickel is an essential catalytic cofactor of enzymes found in eubacteria, archaebacteria,
fungi, and plants. 1-6 These enzymes catalyze a diverse array of reactions that include both …

The nickel metallome describes the distribution and speciation of nickel within the cells of
organisms that utilize this element. This distribution is a consequence of nickel homeostasis …

The importance of cellular low molecular weight ligands in metalloenzyme maturation is
largely unexplored. Maturation of NiSOD requires post-translational N-terminal processing …

Metal-dependent superoxide dismutases (SODs) with a specific requirement for a
manganese or iron ion for catalytic activity and copper-and zinc-dependent enzymes are …

Bacillus megaterium is a bacterium that has been used in the past for the industrial
production of vitamin B 12 (cobalamin), the anti-pernicious anaemia factor. Cobalamin is a …

This chapter presents the definition and brief history of enzymatic biosensors and
biomarkers, their types, and measurement for diagnosis of diseases. The glucose …

Superoxide dismutases are essential enzymes involved in detoxification of reactive oxygen
by dismutation of the superoxide radical anion. A class of nickel containing superoxide …

Background Streptomyces seoulensis has contributed to the discovery and initiation of
extensive research into nickel superoxide dismutase (NiSOD), a unique type of superoxide …

The use of nickel in modern industry and in consumer products implies some health
problems for the human being. Nickel allergy and nickel carcinogenicity are well-known …

3.1 Introduction as far as we know, nickel is non-essential for humans; however,
microorganisms, plants, and some animal species require nickel for survival. 1–3 these …