IgA nephropathy

RJ Wyatt, BA Julian - New England Journal of Medicine, 2013 - Mass Medical Soc
IgA nephropathy is a common glomerular disease that is an important cause of kidney
failure. This review discusses advances in the therapy and understanding of the molecular …

The pathophysiology of IgA nephropathy

H Suzuki, K Kiryluk, J Novak… - Journal of the …, 2011 - journals.lww.com
Here we discuss recent advances in understanding the biochemical, immunologic, and
genetic pathogenesis of IgA nephropathy, the most common primary glomerulonephritis …

[HTML][HTML] Results from part A of the multi-center, double-blind, randomized, placebo-controlled NefIgArd trial, which evaluated targeted-release formulation of …

J Barratt, R Lafayette, J Kristensen, A Stone… - Kidney international, 2023 - Elsevier
The therapeutic potential of a novel, targeted-release formulation of oral budesonide
(Nefecon) for the treatment of IgA nephropathy (IgAN) was first demonstrated by the phase …

Targeted-release budesonide versus placebo in patients with IgA nephropathy (NEFIGAN): a double-blind, randomised, placebo-controlled phase 2b trial

BC Fellström, J Barratt, H Cook, R Coppo, J Feehally… - The Lancet, 2017 - thelancet.com
Background IgA nephropathy is thought to be associated with mucosal immune system
dysfunction, which manifests as renal IgA deposition that leads to impairment and end-stage …

Henoch–Schönlein purpura nephritis in children

JC Davin, R Coppo - Nature Reviews Nephrology, 2014 - nature.com
Henoch–Schönlein purpura (HSP) is the most common vasculitis in children, in whom
prognosis is mostly dependent upon the severity of renal involvement. Nephritis is observed …

The origin and activities of IgA1-containing immune complexes in IgA nephropathy

B Knoppova, C Reily, N Maillard, DV Rizk… - Frontiers in …, 2016 - frontiersin.org
IgA nephropathy (IgAN) is the most common primary glomerulonephritis, frequently leading
to end-stage renal disease, as there is no disease-specific therapy. IgAN is diagnosed from …

Skin ageing: natural weapons and strategies

I Binic, V Lazarevic, M Ljubenovic… - Evidence‐Based …, 2013 - Wiley Online Library
The fact that the skin is the most visible organ makes us aware of the ageing process every
minute. The use of plant extracts and herbs has its origins in ancient times. Chronological …

New insights into the pathogenesis of IgA nephropathy

SC Yeo, CK Cheung, J Barratt - Pediatric Nephrology, 2018 - Springer
IgA nephropathy is the most common form of glomerulonephritis in many parts of the world
and remains an important cause of end-stage renal disease. Current evidence suggests that …

[HTML][HTML] The level of galactose-deficient IgA1 in the sera of patients with IgA nephropathy is associated with disease progression

N Zhao, P Hou, J Lv, Z Moldoveanu, Y Li, K Kiryluk… - Kidney international, 2012 - Elsevier
Although high serum levels of galactose-deficient IgA1 (an important biomarker of IgA
nephropathy (IgAN)) are found in most patients with IgAN, their relationship to disease …

Pathogenesis of IgA nephropathy

KN Lai - Nature Reviews Nephrology, 2012 - nature.com
Since its first description in 1968, IgA nephropathy has remained the most common form of
idiopathic glomerulonephritis leading to chronic kidney disease in developed countries. The …