Bone is an active organ that continuously undergoes an orchestrated process of remodeling
throughout life. Bone tissue is uniquely capable of adapting to loading, hormonal, and other …

Hydrogels are used for 3D in vitro assays and tissue engineering and regeneration
purposes. For a thorough interpretation of this technology, an integral biomechanical …

The recent development of bone-on-chips (BOCs) holds the main advantage of requiring a
low quantity of cells and material, compared to traditional In Vitro models. By incorporating …

Cancer cells have the ability to migrate from the primary (original) site to other places in the
body. The extracellular matrix affects cancer cell migratory capacity and has been correlated …

Bone regeneration is strongly dependent on the capacity of cells to move in a 3D
microenvironment, where a large cascade of signals is activated. To improve the …

Cell migration in 3D is a key process in many physiological and pathological processes.
Although valuable knowledge has been accumulated through analysis of various 2D …

Macrophages play an essential role in the process of recognition and containment of
microbial infections. These immune cells are recruited to infectious sites to reach and …

Addressing current challenges in solid tumor research requires advanced in vitro three-
dimensional (3D) cellular models that replicate the inherently 3D architecture and …

Cell migration is an essential process involved in crucial stages of tissue formation,
regeneration or immune function as well as in pathological processes including tumor …

Two dimensional (2D) cell culture systems lack the ability to mimic in vivo conditions
resulting in limitations for preclinical cell-based drug and toxicity screening assays and …