[HTML][HTML] Innate immunity: the first line of defense against SARS-CoV-2
MS Diamond, TD Kanneganti - Nature immunology, 2022 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute
respiratory syndrome coronavirus (SARS-CoV)-2, continues to cause substantial morbidity …
respiratory syndrome coronavirus (SARS-CoV)-2, continues to cause substantial morbidity …
Biochemistry, cell biology, and pathophysiology of the innate immune cGAS–cGAMP–STING pathway
In the decade since the discovery of the innate immune cyclic GMP–AMP synthase (cGAS)–
2′ 3′-cyclic GMP–AMP (cGAMP)–stimulator of interferon genes (STING) pathway, its …
2′ 3′-cyclic GMP–AMP (cGAMP)–stimulator of interferon genes (STING) pathway, its …
ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for
coronavirus disease 2019 (COVID-19), continues to cause substantial morbidity and …
coronavirus disease 2019 (COVID-19), continues to cause substantial morbidity and …
Pharmacological activation of STING blocks SARS-CoV-2 infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global
pandemic, resulting in millions of infections and deaths with few effective interventions …
pandemic, resulting in millions of infections and deaths with few effective interventions …
A diamidobenzimidazole STING agonist protects against SARS-CoV-2 infection
F Humphries, L Shmuel-Galia, Z Jiang, R Wilson… - Science …, 2021 - science.org
Coronaviruses are a family of RNA viruses that cause acute and chronic diseases of the
upper and lower respiratory tract in humans and other animals. Severe acute respiratory …
upper and lower respiratory tract in humans and other animals. Severe acute respiratory …
[HTML][HTML] Innate immunity, cytokine storm, and inflammatory cell death in COVID-19
R Karki, TD Kanneganti - Journal of Translational Medicine, 2022 - Springer
The innate immune system serves as the first line of defense against invading pathogens;
however, dysregulated innate immune responses can induce aberrant inflammation that is …
however, dysregulated innate immune responses can induce aberrant inflammation that is …
The SARS-CoV-2 papain-like protease suppresses type I interferon responses by deubiquitinating STING
D Cao, L Duan, B Huang, Y Xiong, G Zhang… - Science Signaling, 2023 - science.org
The SARS-CoV-2 papain-like protease (PLpro), which has deubiquitinating activity,
suppresses the type I interferon (IFN-I) antiviral response. We investigated the mechanism …
suppresses the type I interferon (IFN-I) antiviral response. We investigated the mechanism …
Drug combinations as a first line of defense against coronaviruses and other emerging viruses
The world was unprepared for coronavirus disease 2019 (COVID-19) and remains ill-
equipped for future pandemics. While unprecedented strides have been made developing …
equipped for future pandemics. While unprecedented strides have been made developing …
[HTML][HTML] Host cell-intrinsic innate immune recognition of SARS-CoV-2
EA Madden, MS Diamond - Current opinion in virology, 2022 - Elsevier
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged at the end of
2019 and caused the pandemic of coronavirus disease 2019 (COVID-19). Basic and clinical …
2019 and caused the pandemic of coronavirus disease 2019 (COVID-19). Basic and clinical …
[HTML][HTML] Nsp1 proteins of human coronaviruses HCoV-OC43 and SARS-CoV2 inhibit stress granule formation
SM Dolliver, M Kleer, MP Bui-Marinos, S Ying… - PLoS …, 2022 - journals.plos.org
Stress granules (SGs) are cytoplasmic condensates that often form as part of the cellular
antiviral response. Despite the growing interest in understanding the interplay between SGs …
antiviral response. Despite the growing interest in understanding the interplay between SGs …