Various stress factors leading to protein damage induce the activation of an evolutionarily
conserved cell protective mechanism, the heat shock response (HSR), to maintain protein …

Ethanol (EtOH) has effects on numerous cellular molecular targets, and alterations in
synaptic function are prominent among these effects. Acute exposure to EtOH activates or …

Neuroimmune pathways regulate brain function to influence complex behavior and play a
role in several neuropsychiatric diseases, including alcohol use disorder (AUD). In …

Recent studies have suggested an association between alcoholism and DNA methylation, a
mechanism that can mediate long-lasting changes in gene transcription. Here, we examined …

Immune or brain proinflammatory signaling has been linked to some of the behavioral
effects of alcohol. Immune signaling appears to regulate voluntary ethanol intake in rodent …

We have used a translational Convergent Functional Genomics (CFG) approach to discover
genes involved in alcoholism, by gene-level integration of genome-wide association study …

Sensitivity to ethanol intoxication, propensity to drink ethanol and vulnerability to develop
alcoholism are all influenced by genetic factors. Conversely, exposure to ethanol or …

Networks of neuronal synapses are the fundamental basis for making and retaining memory.
Reduced synapse number and quality correlates with loss of memory in dementia. Heat …

Background Alcohol addiction is characterized by persistent neuroadaptations in brain
structures involved in motivation, emotion, and decision making, including the medial …

The cellular environment needs to be strongly regulated and the maintenance of protein
homeostasis is crucial for cell function and survival. HSF1 is the main regulator of the heat …