Eph receptor tyrosine kinases play critical functions during development, in the formation of
tissue and organ borders, and the vascular and neural systems. Uniquely among tyrosine …

Simple Summary This narrative literature review delves into the role of EPH/ephrin signaling
in liver cancer and its implications for tumor progression and potential therapeutic strategies …

Recent studies have shown that peripheral nerves play an important role in the progression
of breast cancer. Breast cancer cells (BCCs) promote local peripheral nerve growth and …

Triple-negative breast cancer (TNBC) is the most elusive subtype of breast cancer that
encounters treatment dilemmas owing to the paucity of druggable targets. We found …

Simple Summary Triple negative breast cancer (TNBC) is the most aggressive subtype of
breast cancer, with a higher mortality rate when compared to the other subtypes. Because of …

We propose an overview of the molecular cues and their intracellular signaling involved in
the crosstalk between cancer and the nervous system. While “cancer neuroscience” as a …

Ephrin type A receptor 2 (EphA2) binds to membrane-bound ligands, ephrin A1, A2, and A5,
eliciting bidirectional signaling. This signaling regulates many physiological processes, such …

Erythropoietin-producing hepatocellular A2 (EphA2) is a member of the Eph tyrosine kinase
receptor family that has been linked to various biological processes. In tumors, EphA2 …

Breast cancer (BCA) remains the leading cause of cancer-related mortality among women
worldwide. This review delves into the therapeutic challenges of BCA, emphasizing the roles …

Abstract Background Triple-Negative Breast Cancer is particularly aggressive, and its
metastasis to the brain has a significant psychological impact on patients' quality of life, in …