(Macro) autophagy is a bulk degradation process that mediates the clearance of long-lived
proteins and organelles. Autophagy is initiated by double-membraned structures, which …

Over the past 20 years, the concept of mammalian autophagy as a nonselective degradation
system has been repudiated, due in part to important discoveries in neurodegenerative …

Human genetics has indicated a causal role for the protein α-synuclein in the pathogenesis
of familial Parkinson's disease (PD), and the aggregation of synuclein in essentially all …

Many late-onset neurodegenerative diseases, including Parkinson's disease and
Huntington's disease, are associated with the formation of intracellular aggregates by toxic …

Mitochondrial dysregulation is strongly implicated in Parkinson disease. Mutations in PTEN-
induced kinase 1 (PINK1) are associated with familial parkinsonism and neuropsychiatric …

Macroautophagy, a major pathway for organelle and protein turnover, has been implicated
in the neurodegeneration of Alzheimer's disease (AD). The basis for the profuse …

The accumulation of misfolded proteins in intracellular amyloid inclusions, typical of many
neurodegenerative disorders including Huntington's and prion disease, is thought to occur …

A prominent feature of late-onset neurodegenerative diseases is accumulation of misfolded
protein in vulnerable neurons. When levels of misfolded protein overwhelm degradative …

Aggregation and cleavage are two hallmarks of Tau pathology in Alzheimer disease (AD),
and abnormal fragmentation of Tau is thought to contribute to the nucleation of Tau paired …

ABSTRACT TAR DNA-binding protein (TDP-43, also known as TARDBP) is the major
pathological protein in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia …