The incidence of fungal diseases has been increasing since 1980, and is associated with
excessive morbidity and mortality, particularly among immunosuppressed patients. Of the …

Aspergillus species are the major cause of health concern worldwide in
immunocompromised individuals. Opportunistic Aspergilli cause invasive to allergic …

In order to survive, Aspergillus fumigatus must adapt to specific niche environments.
Adaptation to the human host includes modifications facilitating persistent colonisation and …

Although considered effective treatment for many yeast fungi, the therapeutic efficacy of the
echinocandin class of antifungals for invasive aspergillosis (IA) is limited. Recent studies …

The Aspergillus fumigatus unfolded protein response (UPR) is a two-component relay
consisting of the ER-bound IreA protein, which splices and activates the mRNA of the …

Infections by fungal pathogens are difficult to treat due to a paucity of antifungals and
emerging resistances. Next-generation antifungals therefore are needed urgently. We have …

Invasive aspergillosis is a deadly fungal disease; more than 400,000 patients are infected
worldwide each year and the mortality rate can be as high as 50-95%. Of the~ 450 species …

The human host comprises a range of specific niche environments. In order to successfully
persist, pathogens such as Aspergillus fumigatus must adapt to these environments. One …

Post‐translational farnesylation can regulate subcellular localization and protein–protein
interaction in eukaryotes. The function of farnesylation is not well identified in plant …

Phosphatidylcholines (PCs) are a class of cell membrane phospholipids playing important
roles in cellular integrity and signaling. In eukaryotes, PCs are biosynthesized via the …