Sepsis, defined as an infection with dysregulated host response leading to life‐threatening
organ dysfunction, continues to carry a high potential for morbidity and mortality in children …

Sepsis is a leading cause of death and the target of intense efforts to improve recognition,
management and outcomes. Accurate sepsis surveillance is essential to properly …

BACKGROUND AND OBJECTIVES: To explore the microbiologic etiology and trends in
incidence and survival of nonneonatal pediatric sepsis in the United States by using the …

Background Devastating cases of sepsis in previously healthy patients have received
widespread attention and have helped to catalyze state and national mandates to improve …

Objectives: To describe the Children's Hospital Association's Improving Pediatric Sepsis
Outcomes sepsis definitions and the identified patients; evaluate the definition using a …

Background Children with community-acquired septic shock can rapidly deteriorate and die
in acute-care hospitals. This study aimed to describe the mortality, timing, and risk factors in …

Background Presumed serious infection (PSI) is defined as a blood culture drawn and new
antibiotic course of at least 4 days among pediatric patients with Central Venous Lines …

OBJECTIVES: To validate a computational phenotype that identifies acute brain dysfunction
(ABD) based on clinician concern for neurologic or behavioral changes in pediatric sepsis …

Background Most multicenter studies of US pediatric sepsis epidemiology use administrative
data or focus on pediatric intensive care units. We conducted a detailed medical record …

Objective: Predict the onset of presumed serious infection, defined as a positive blood
culture drawn and new antibiotic course of at least 4 days (PSI*), among pediatric patients …