Cancer cachexia is a complex multi‐organ catabolic syndrome that reduces mobility,
increases fatigue, decreases the efficiency of therapeutic strategies, diminishes the quality of …

Advanced cancer patients exhibit cachexia, a condition characterized by a significant
reduction in the body weight predominantly from loss of skeletal muscle and adipose tissue …

Tissue sensitivity and response to exercise vary according to the time of day and alignment
of circadian clocks, but the optimal exercise time to elicit a desired metabolic outcome is not …

Breast cancer represents the most commonly diagnosed cancer while neoadjuvant and
adjuvant chemotherapies are extensively used in order to reduce tumor development and …

Background Cancer-associated cachexia is a multi-organ disorder associated with
progressive weight loss due to a variable combination of anorexia, systemic inflammation …

Low molecular weight metabolites are essential for defining the molecular phenotypes of
cells. However, spatial metabolomics tools often lack the sensitivity, specify, and spatial …

Background Cancer is associated with muscle atrophy (cancer cachexia) that is linked to up
to 40% of cancer‐related deaths. Oxidative stress is a critical player in the induction and …

Regressing the accelerated degradation of skeletal muscle protein is a significant goal for
cancer cachexia management. Here, we show that genetic deletion of Pgam5 ameliorates …

Objective Sarcopenia is a common complication of COPD associated with an age-related
reduction in skeletal muscle mass associated with decreased muscle strength and/or …

Background Cancer cachexia is a multifactorial metabolic syndrome characterized by
systemic inflammation and ongoing skeletal muscle loss resulting in weakness, poor quality …