It has been six years since the first reported link between mutations in the cardiac ryanodine
receptor Ca2+ release channel (RyR2) and catecholaminergic polymorphic ventricular …

Ryanodine receptors (RyRs) are colossal membrane protein complexes that reside in the
endoplasmic reticulum of skeletal and cardiac muscle myocytes and neurons, in addition to …

Excitation-contraction coupling (ECC) is a fundamental mechanism in control of skeletal
muscle contraction and occurs at triad junctions, where dihydropyridine receptors (DHPRs) …

Ryanodine receptor–calcium release channels play a pivotal role in the calcium signaling
that mediates muscle excitation–contraction coupling. Their membrane organization into …

Aims Our objective was to explore the functional interdependence of protein kinase A (PKA)
phosphorylation with binding of modulatory FK506 binding proteins (FKBP12/12.6) to the …

The ryanodine receptor (RyR) is an intracellular calcium release channel located on the
sarco (endo) plasmic reticulum of muscle and non-muscle cells. The functional channel is …

Ryanodine receptor (RyR) Ca2+ release channels undergo a conformational change
between the open and closed states. Its protein modulator, FK506 binding protein 12 …

Identification of the genetic basis of human diseases linked to dysfunctional free calcium (Ca
2+) signaling has triggered an explosion of interest in the functional characterization of the …

The immunophilin, FK506-binding protein (FKBP12), is an essential component of the
ryanodine receptor channel complex of skeletal muscle (RyR1) and modulates intracellular …

To elucidate the possible role of candidate protein-coding genes in 13q14 in the
pathomechanism associated with deletion of this region (the most common genomic …