Structural basis of a redox-dependent conformational switch that regulates the stress kinase p38α

J Pous, B Baginski, P Martin-Malpartida… - Nature …, 2023 - nature.com
Many functional aspects of the protein kinase p38α have been illustrated by more than three
hundred structures determined in the presence of reducing agents. These structures …

Quantification of binding of small molecules to native proteins overexpressed in living cells

Y Yin, SL Zhao, D Rane, Z Lin, M Wu… - Journal of the …, 2023 - ACS Publications
The affinity and selectivity of small molecules for proteins drive drug discovery and
development. We report a fluorescent probe cellular binding assay (FPCBA) for …

3-hydroxycoumarin effectively inhibits development and pathogenicity by targeting Pempk proteins of Penicillium expansum

R Zhuo, X Zhang, Y Chen, M Xing, S Tian… - Postharvest Biology and …, 2024 - Elsevier
Penicillium expansum, a causal agent of blue mold rot, leads to substantial postharvest
losses in the fruit industry. Due to environmental pollution and the emergence of fungicide …

Transport spectroscopy study of minibands in moiré superlattices

CH Sharma, M Prada, JH Schmidt… - Physical Review B, 2024 - APS
The exotic correlated phases that emerge in the low-dispersing moiré bands of twisted van
der Waals structures have opened new exciting opportunities in condensed-matter physics …

Calciprotein Particles Induce Cellular Compartment-Specific Proteome Alterations in Human Arterial Endothelial Cells

D Shishkova, A Lobov, E Repkin, V Markova… - Journal of …, 2023 - mdpi.com
Calciprotein particles (CPPs) are indispensable scavengers of excessive Ca2+ and PO43−
ions in blood, being internalised and recycled by liver and spleen macrophages, monocytes …

Structural basis of a redox-dependent conformational switch that regulates the stress kinase p38α

M Macias, J Pous, B Baginski, P Martin-Malpartida… - 2023 - researchsquare.com
Many functional aspects of the protein kinase p38α have been illustrated by more than three
hundred structures, covering free forms and complexes with activators, substrates and …