Background With the increasing ages of the general population, the incidence of knee
osteoarthritis (KOA) is also rising, and KOA has become a major health problem worldwide …

Purpose To provide an updated review of the literature on the use of orthobiologics as a
potential treatment option to alleviate symptoms associated with osteoarthritis (OA), slow the …

Injury of articular cartilage leads to an imbalance in tissue homeostasis, and due to the poor
self-healing capacity of cartilage the affected tissue often exhibits osteoarthritic changes. In …

Osteoarthritis (OA) is a painful and disabling disease that affects millions of people
worldwide. Symptom-alleviating treatments exist, although none with long-term efficacy …

Naturally occurring coumestans are known as a collection of plant-derived polycyclic
aromatic secondary metabolites which are characterized by the presence of an oxygen …

Osteoarthritis (OA) is one of the most common musculoskeletal degenerative diseases and
contributes to heavy socioeconomic burden. Current pharmacological and conventional non …

Rhein, a natural anthraquinone compound derived from traditional Chinese medicine,
exhibits potent anti-inflammatory properties via modulating the level of Reactive oxygen or …

Background: Knee osteoarthritis (KOA), a chronic degenerative disease, is mainly
characterized by destruction of articular cartilage and inflammatory reactions. At present …

In osteoarthritis (OA), inhibition of excessively expressed pro-inflammatory cytokines in the
OA joint and increasing the anabolism for cartilage regeneration are necessary. In this ex …

Osteoarthritis (OA) is a common chronic degenerative joint disease in clinical practice with a
high prevalence, especially in the elderly. Traditional Chinese Medicine (TCM) believes that …