Aneuploidy has been recognized as a hallmark of tumorigenesis for more than 100 years,
but the connection between chromosomal errors and malignant growth has remained …

Mitosis is a delicate event that must be executed with high fidelity to ensure genomic
stability. Recent work has provided insight into how mitotic errors shape cancer genomes by …

Inactivation of the RB protein is one of the most fundamental events in cancer. Coming to a
molecular understanding of its function in normal cells and how it impedes cancer …

Chromosomal aberrations during cell division represent one of the first recognized features
of human cancer cells, and modern detection methods have revealed the pervasiveness of …

Most solid human tumours are aneuploid, that is, they contain an abnormal number of
chromosomes. Paradoxically, however, aneuploidy has been reported to induce a stress …

Faithful chromosome segregation during mitosis is essential for genome integrity and is
mediated by the bi-oriented attachment of replicated chromosomes to spindle microtubules …

Cyclins B1 and B2 are frequently elevated in human cancers and are associated with
tumour aggressiveness and poor clinical outcome; however, whether and how B-type …

Chromosomal instability (CIN) is one of the major forms of genomic instability in various
human cancers and is recognized as a common hallmark of tumorigenesis and …

Many cancers display both structural (s-CIN) and numerical (w-CIN) chromosomal
instabilities. Defective chromosome segregation during mitosis has been shown to cause …

Aneuploidy and chromosomal instability frequently co-exist, and aneuploidy is recognized
as a direct outcome of chromosomal instability. However, chromosomal instability is widely …