Matrigel, a basement-membrane matrix extracted from Engelbreth–Holm–Swarm mouse
sarcomas, has been used for more than four decades for a myriad of cell-culture …

Hematopoietic stem cells (HSCs) are the life-long source of all types of blood cells. Their
function is controlled by their direct microenvironment, the HSC niche in the bone marrow …

The bone marrow is the home of hematopoiesis and is therefore a hotspot for the
development of hematopoietic diseases. Complex interactions between the bone marrow …

Hematologic malignancies (HMs) pose a serious threat to patients' health and life, and the
five-year overall survival of HMs remains low. The lack of understanding of the pathogenesis …

Calcium phosphate (Ca-P) bioceramics, including hydroxyapatite (HA), biphasic calcium
phosphate (BCP), and beta-tricalcium phosphate (β-TCP), have been widely used in bone …

Cancer progression is associated with extensive remodeling of the tumor microenvironment
(TME), resulting in alterations of biochemical and biophysical cues that affect both cancer …

Tumors are not merely cancerous cells that undergo mindless proliferation. Rather, they are
highly organized and interconnected organ systems. Tumor cells reside in complex …

Human malignant hematopoietic stem and progenitor cells (HSPCs) reside in bone marrow
(BM) niches, which remain challenging to explore due to limited in vivo accessibility and …

The bone marrow (BM) is the primary site of adult haematopoiesis, where stromal elements
(eg fibroblasts and mesenchymal stem cells [MSCs]) work in concert to support blood cell …

Cancer treatment is challenged by the heterogeneous nature of cancer, where prognosis
depends on tumor type and disease stage, as well as previous treatments. Optimal patient …