Role of phytochemicals in cancer prevention

A Ranjan, S Ramachandran, N Gupta… - International journal of …, 2019 - mdpi.com
The use of synthetic, natural, or biological agents to minimize the occurrence of cancer in
healthy individuals is defined as cancer chemoprevention. Chemopreventive agents inhibit …

Piperlongumine, a potent anticancer phytotherapeutic: Perspectives on contemporary status and future possibilities as an anticancer agent

SK Tripathi, BK Biswal - Pharmacological Research, 2020 - Elsevier
Piperlongumine, a white to beige biologically active alkaloid/amide phytochemical, has high
pharmacological relevance as an anticancer agent. Piperlongumine has several biological …

The influence of alkaloids on oxidative stress and related signaling pathways

K Macáková, R Afonso, L Saso, P Mladěnka - Free Radical Biology and …, 2019 - Elsevier
Alkaloids have always attracted scientific interest due to either their positive or negative
effects on human beings. This review aims to summarize their antioxidant effects by both …

[HTML][HTML] Phytotherapeutic applications of alkaloids in treating breast cancer

S Rampogu, T Balasubramaniyam, JH Lee - Biomedicine & …, 2022 - Elsevier
Breast cancer is one of the major causes of mortality in women worldwide. The current
treatments available are radiation therapy (RT), surgery, endocrine (hormone) therapy (ET) …

[HTML][HTML] Piperlongumine induces ROS mediated cell death and synergizes paclitaxel in human intestinal cancer cells

L Rawat, H Hegde, SL Hoti, V Nayak - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Piperlongumine (PL), a herbal drug extracted from long pepper (Piper longum L), is known
for its anti-inflammatory and anti-cancer properties. Although, its anti-cancer potential has …

Alkaloids as natural NRF2 inhibitors: Chemoprevention and cytotoxic action in Cancer

D Gjorgieva Ackova, V Maksimova, K Smilkov… - Pharmaceuticals, 2023 - mdpi.com
Being a controller of cytoprotective actions, inflammation, and mitochondrial function through
participating in the regulation of multiple genes in response to stress-inducing endogenous …

Recent advances in pancreatic cancer: biology, treatment, and prevention

D Singh, G Upadhyay, RK Srivastava… - Biochimica et Biophysica …, 2015 - Elsevier
Pancreatic cancer (PC) is the fourth leading cause of cancer-related death in United States.
Efforts have been made towards the development of the viable solution for its treatment with …

Piperlongumine inhibits lung tumor growth via inhibition of nuclear factor kappa B signaling pathway

J Zheng, DJ Son, SM Gu, JR Woo, YW Ham, HP Lee… - Scientific reports, 2016 - nature.com
Piperlongumine has anti-cancer activity in numerous cancer cell lines via various signaling
pathways. But there has been no study regarding the mechanisms of PL on the lung cancer …

Piperlongumine increases sensitivity of colorectal cancer cells to radiation: Involvement of ROS production via dual inhibition of glutathione and thioredoxin systems

H Wang, H Jiang, C Corbet, S de Mey, K Law… - Cancer letters, 2019 - Elsevier
Piperlongumine (PL), naturally synthesized in long pepper, is known to selectively kill tumor
cells via perturbation of reactive oxygen species (ROS) homeostasis. ROS are the primary …

Emerging importance of dietary phytochemicals in fight against cancer: role in targeting cancer stem cells

AK Singh, N Sharma, M Ghosh, YH Park… - Critical reviews in food …, 2017 - Taylor & Francis
Recent years have seen an unpretending increase in research using dietary phytochemicals
for targeting cancer and cancer stem cells (CSCs) due to the limited efficacy of conventional …