Role of phytochemicals in cancer prevention
The use of synthetic, natural, or biological agents to minimize the occurrence of cancer in
healthy individuals is defined as cancer chemoprevention. Chemopreventive agents inhibit …
healthy individuals is defined as cancer chemoprevention. Chemopreventive agents inhibit …
Piperlongumine, a potent anticancer phytotherapeutic: Perspectives on contemporary status and future possibilities as an anticancer agent
SK Tripathi, BK Biswal - Pharmacological Research, 2020 - Elsevier
Piperlongumine, a white to beige biologically active alkaloid/amide phytochemical, has high
pharmacological relevance as an anticancer agent. Piperlongumine has several biological …
pharmacological relevance as an anticancer agent. Piperlongumine has several biological …
The influence of alkaloids on oxidative stress and related signaling pathways
K Macáková, R Afonso, L Saso, P Mladěnka - Free Radical Biology and …, 2019 - Elsevier
Alkaloids have always attracted scientific interest due to either their positive or negative
effects on human beings. This review aims to summarize their antioxidant effects by both …
effects on human beings. This review aims to summarize their antioxidant effects by both …
[HTML][HTML] Phytotherapeutic applications of alkaloids in treating breast cancer
S Rampogu, T Balasubramaniyam, JH Lee - Biomedicine & …, 2022 - Elsevier
Breast cancer is one of the major causes of mortality in women worldwide. The current
treatments available are radiation therapy (RT), surgery, endocrine (hormone) therapy (ET) …
treatments available are radiation therapy (RT), surgery, endocrine (hormone) therapy (ET) …
[HTML][HTML] Piperlongumine induces ROS mediated cell death and synergizes paclitaxel in human intestinal cancer cells
Piperlongumine (PL), a herbal drug extracted from long pepper (Piper longum L), is known
for its anti-inflammatory and anti-cancer properties. Although, its anti-cancer potential has …
for its anti-inflammatory and anti-cancer properties. Although, its anti-cancer potential has …
Alkaloids as natural NRF2 inhibitors: Chemoprevention and cytotoxic action in Cancer
Being a controller of cytoprotective actions, inflammation, and mitochondrial function through
participating in the regulation of multiple genes in response to stress-inducing endogenous …
participating in the regulation of multiple genes in response to stress-inducing endogenous …
Recent advances in pancreatic cancer: biology, treatment, and prevention
D Singh, G Upadhyay, RK Srivastava… - Biochimica et Biophysica …, 2015 - Elsevier
Pancreatic cancer (PC) is the fourth leading cause of cancer-related death in United States.
Efforts have been made towards the development of the viable solution for its treatment with …
Efforts have been made towards the development of the viable solution for its treatment with …
Piperlongumine inhibits lung tumor growth via inhibition of nuclear factor kappa B signaling pathway
J Zheng, DJ Son, SM Gu, JR Woo, YW Ham, HP Lee… - Scientific reports, 2016 - nature.com
Piperlongumine has anti-cancer activity in numerous cancer cell lines via various signaling
pathways. But there has been no study regarding the mechanisms of PL on the lung cancer …
pathways. But there has been no study regarding the mechanisms of PL on the lung cancer …
Piperlongumine increases sensitivity of colorectal cancer cells to radiation: Involvement of ROS production via dual inhibition of glutathione and thioredoxin systems
Piperlongumine (PL), naturally synthesized in long pepper, is known to selectively kill tumor
cells via perturbation of reactive oxygen species (ROS) homeostasis. ROS are the primary …
cells via perturbation of reactive oxygen species (ROS) homeostasis. ROS are the primary …
Emerging importance of dietary phytochemicals in fight against cancer: role in targeting cancer stem cells
Recent years have seen an unpretending increase in research using dietary phytochemicals
for targeting cancer and cancer stem cells (CSCs) due to the limited efficacy of conventional …
for targeting cancer and cancer stem cells (CSCs) due to the limited efficacy of conventional …