Central serous chorioretinopathy (CSC) is a common cause of central vision loss, primarily
affecting men 20–60 years of age. To date, no consensus has been reached regarding the …

Since their invention in the early 2000s, tyrosine kinase inhibitors (TKIs) have gained
prominence as the most effective pathway-directed anti-cancer agents. TKIs have shown …

Central serous chorioretinopathy (CSC) is a common form of vision loss, typically seen in
working-age men. The pathophysiology behind CSC still eludes us, however significant …

The inhibition of the mitogen-activated protein kinases signalling pathway through combined
use of BRAF and MEK inhibitors (BRAFi+ MEKi) represents an established therapeutic …

Gliomas are molecularly heterogeneous brain tumors responsible for the most years of life
lost by any cancer. High-grade gliomas have a poor prognosis and despite multimodal …

The most frequent site of ocular metastasis is the choroid. The occurrence of choroidal
metastases has increased steadily due to the longer survival of metastatic patients and the …

A wide range of ocular diseases can present with serous subretinal fluid in the macula and
therefore clinically mimic central serous chorioretinopathy (CSC). In this manuscript, we …

Purpose: Mitogen-activates protein kinase (MAPK) inhibitors, particularly MEK inhibitors,
have shifted the treatment paradigm for metastatic BRAF-mutant cutaneous melanoma; …

Mitogen-activated protein kinase (MAPK) pathways represent ubiquitous cellular signal
transduction pathways that regulate all aspects of life and are frequently altered in disease …

Compared with high-grade serous carcinoma, low-grade serous carcinoma of the ovary or
peritoneum is a less frequent epithelial ovarian cancer type that is poorly sensitive to …