PSMA radioligand therapy for solid tumors other than prostate cancer: background, opportunities, challenges, and first clinical reports

MJM Uijen, YHW Derks, RIJ Merkx… - European journal of …, 2021 - Springer
In the past decade, a growing body of literature has reported promising results for prostate-
specific membrane antigen (PSMA)-targeted radionuclide imaging and therapy in prostate …

PSMA radioligand uptake as a biomarker of neoangiogenesis in solid tumours: diagnostic or theragnostic factor?

A Rizzo, S Dall'Armellina, DA Pizzuto, G Perotti… - Cancers, 2022 - mdpi.com
Simple Summary Positron emission tomography/computed tomography (PET/CT) has an
increasingly relevant role in the management of oncological patients. It consists of the …

68Ga-PSMA-11 PET/CT improves tumor detection and impacts management in patients with hepatocellular carcinoma

N Hirmas, C Leyh, M Sraieb, F Barbato… - Journal of Nuclear …, 2021 - Soc Nuclear Med
Hepatocellular carcinoma (HCC) is the sixth most prevalent cancer and the third most
frequent cause of cancer-related death. A growing number of local and systemic therapies …

Synthesis and preclinical evaluation of a 68Ga-labeled adnectin, 68Ga-BMS-986192, as a PET agent for imaging PD-L1 expression

S Robu, A Richter, D Gosmann, C Seidl… - Journal of Nuclear …, 2021 - Soc Nuclear Med
Blocking the interaction of the immune checkpoint molecule programmed cell death protein-
1 and its ligand, PD-L1, using specific antibodies has been a major breakthrough for …

[PDF][PDF] PSMA as a Theranostic Target in Hepatocellular Carcinoma: Immunohistochemistry and 68Ga‐PSMA‐11 PET Using Cyclotron‐Produced 68Ga

SM Thompson, G Suman… - Hepatology …, 2022 - Wiley Online Library
Prostate‐specific membrane antigen (PSMA) is a validated target for molecular diagnostics
and targeted radionuclide therapy. Our purpose was to evaluate PSMA expression in …

[68 Ga]Ga-Prostate-Specific Membrane Antigen PET/CT: a novel method for imaging patients with hepatocellular carcinoma

J Kunikowska, B Cieślak, B Gierej, W Patkowski… - European Journal of …, 2021 - Springer
Purpose Prostate-specific membrane antigen (PSMA) is not only highly expressed on the
surface prostate cancer cells but is also elevated during angiogenesis in other cancer cell …

Targeted Endoradiotherapy with Lu2O3-iPSMA/-iFAP Nanoparticles Activated by Neutron Irradiation: Preclinical Evaluation and First Patient Image

M Luna-Gutiérrez, B Ocampo-García… - Pharmaceutics, 2022 - mdpi.com
Prostate-specific membrane antigen (PSMA) is expressed in a variety of cancer cells, while
the fibroblast activation protein (FAP) is expressed in the microenvironment of tumors …

Advances in development of radiometal labeled amino acid-based compounds for cancer imaging and diagnostics

MB Mikulová, P Mikuš - Pharmaceuticals, 2021 - mdpi.com
Radiolabeled biomolecules targeted at tumor-specific enzymes, receptors, and transporters
in cancer cells represent an intensively investigated and promising class of molecular tools …

Advanced radionuclides in diagnosis and therapy for hepatocellular carcinoma

H Chen, M Teng, H Zhang, X Liang, H Cheng… - Chinese Chemical …, 2022 - Elsevier
Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver,
but early diagnosis and effective treatment are still difficult. With the development of …

Synthesis, chemical and biochemical characterization of Lu2O3-iPSMA nanoparticles activated by neutron irradiation

A Ancira-Cortez, G Ferro-Flores… - Materials Science and …, 2020 - Elsevier
Among the nanomaterials, rare sesquioxides (lanthanide oxides such as Lu 2 O 3) are of
interest due to their adequate thermal conductivity, excellent chemical stability, and high …