The neural basis of reversal learning: An updated perspective

A Izquierdo, JL Brigman, AK Radke, PH Rudebeck… - Neuroscience, 2017 - Elsevier
Reversal learning paradigms are among the most widely used tests of cognitive flexibility
and have been used as assays, across species, for altered cognitive processes in a host of …

Glutamatergic regulation of cognition and functional brain connectivity: insights from pharmacological, genetic and translational schizophrenia research

MR Dauvermann, G Lee… - British journal of …, 2017 - Wiley Online Library
The pharmacological modulation of glutamatergic neurotransmission to improve cognitive
function has been a focus of intensive research, particularly in relation to the cognitive …

Touchscreen cognitive deficits, hyperexcitability and hyperactivity in males and females using two models of Cdkl5 deficiency

A Adhikari, FKB Buchanan, TA Fenton… - Human molecular …, 2022 - academic.oup.com
Many neurodevelopmental disorders (NDDs) are the result of mutations on the X
chromosome. One severe NDD resulting from mutations on the X chromosome is CDKL5 …

[HTML][HTML] KHSRP loss increases neuronal growth and synaptic transmission and alters memory consolidation through RNA stabilization

SL Olguin, P Patel, CN Buchanan, M Dell'Orco… - Communications …, 2022 - nature.com
The KH-type splicing regulatory protein (KHSRP) is an RNA-binding protein linked to decay
of mRNAs with AU-rich elements. KHSRP was previously shown to destabilize Gap43 …

Prenatal nicotine exposure in mice induces sex-dependent anxiety-like behavior, cognitive deficits, hyperactivity, and changes in the expression of glutamate receptor …

FS Polli, MB Scharff, TH Ipsen, S Aznar… - Pharmacology …, 2020 - Elsevier
In rodents, prenatal nicotine exposure (PNE) has been associated with increased risk for
development of cognitive and emotional disturbances, but the findings are somewhat …

Transcranial low-intensity pulsed ultrasound modulates structural and functional synaptic plasticity in rat hippocampus

X Huang, Z Lin, K Wang, X Liu, W Zhou… - IEEE Transactions …, 2019 - ieeexplore.ieee.org
Plasticity of synaptic structure and function play an essential role in neuronal development,
cognitive functions, and degenerative diseases. Recently, low-intensity pulsed ultrasound …

Moderate prenatal alcohol exposure impairs cognitive control, but not attention, on a rodent touchscreen continuous performance task

SL Olguin, SM Thompson, JW Young… - Genes, Brain and …, 2021 - Wiley Online Library
A common feature associated with fetal alcohol spectrum disorders is the inability to
concentrate on a specific task while ignoring distractions. Human continuous performance …

Molecular and cellular dissection of NMDA receptor subtypes as antidepressant targets

E Lang, AS Mallien, AN Vasilescu, D Hefter… - Neuroscience & …, 2018 - Elsevier
A growing body of evidence supports the idea that drugs targeting the glutamate system may
represent a valuable therapeutic alternative in major depressive disorders (MDD). The rapid …

Targeting the dysfunction of glutamate receptors for the development of novel antidepressants

CY Xia, J He, LD Du, Y Yan, WW Lian, JK Xu… - Pharmacology & …, 2021 - Elsevier
Increasing evidence indicates that dysfunction of glutamate receptors is involved in the
pathophysiology of major depressive disorder (MDD). Although accumulating efforts have …

Assessment of cognitive functions in animal models of schizophrenia

A Nikiforuk - Pharmacological Reports, 2018 - Elsevier
Impaired cognitive functioning is recognized as an integral feature of schizophrenia. These
deficits have emerged not only as an important predictor of clinical and social outcomes but …