The neural basis of reversal learning: An updated perspective
Reversal learning paradigms are among the most widely used tests of cognitive flexibility
and have been used as assays, across species, for altered cognitive processes in a host of …
and have been used as assays, across species, for altered cognitive processes in a host of …
Glutamatergic regulation of cognition and functional brain connectivity: insights from pharmacological, genetic and translational schizophrenia research
MR Dauvermann, G Lee… - British journal of …, 2017 - Wiley Online Library
The pharmacological modulation of glutamatergic neurotransmission to improve cognitive
function has been a focus of intensive research, particularly in relation to the cognitive …
function has been a focus of intensive research, particularly in relation to the cognitive …
Touchscreen cognitive deficits, hyperexcitability and hyperactivity in males and females using two models of Cdkl5 deficiency
A Adhikari, FKB Buchanan, TA Fenton… - Human molecular …, 2022 - academic.oup.com
Many neurodevelopmental disorders (NDDs) are the result of mutations on the X
chromosome. One severe NDD resulting from mutations on the X chromosome is CDKL5 …
chromosome. One severe NDD resulting from mutations on the X chromosome is CDKL5 …
[HTML][HTML] KHSRP loss increases neuronal growth and synaptic transmission and alters memory consolidation through RNA stabilization
The KH-type splicing regulatory protein (KHSRP) is an RNA-binding protein linked to decay
of mRNAs with AU-rich elements. KHSRP was previously shown to destabilize Gap43 …
of mRNAs with AU-rich elements. KHSRP was previously shown to destabilize Gap43 …
Prenatal nicotine exposure in mice induces sex-dependent anxiety-like behavior, cognitive deficits, hyperactivity, and changes in the expression of glutamate receptor …
In rodents, prenatal nicotine exposure (PNE) has been associated with increased risk for
development of cognitive and emotional disturbances, but the findings are somewhat …
development of cognitive and emotional disturbances, but the findings are somewhat …
Transcranial low-intensity pulsed ultrasound modulates structural and functional synaptic plasticity in rat hippocampus
Plasticity of synaptic structure and function play an essential role in neuronal development,
cognitive functions, and degenerative diseases. Recently, low-intensity pulsed ultrasound …
cognitive functions, and degenerative diseases. Recently, low-intensity pulsed ultrasound …
Moderate prenatal alcohol exposure impairs cognitive control, but not attention, on a rodent touchscreen continuous performance task
SL Olguin, SM Thompson, JW Young… - Genes, Brain and …, 2021 - Wiley Online Library
A common feature associated with fetal alcohol spectrum disorders is the inability to
concentrate on a specific task while ignoring distractions. Human continuous performance …
concentrate on a specific task while ignoring distractions. Human continuous performance …
Molecular and cellular dissection of NMDA receptor subtypes as antidepressant targets
E Lang, AS Mallien, AN Vasilescu, D Hefter… - Neuroscience & …, 2018 - Elsevier
A growing body of evidence supports the idea that drugs targeting the glutamate system may
represent a valuable therapeutic alternative in major depressive disorders (MDD). The rapid …
represent a valuable therapeutic alternative in major depressive disorders (MDD). The rapid …
Targeting the dysfunction of glutamate receptors for the development of novel antidepressants
CY Xia, J He, LD Du, Y Yan, WW Lian, JK Xu… - Pharmacology & …, 2021 - Elsevier
Increasing evidence indicates that dysfunction of glutamate receptors is involved in the
pathophysiology of major depressive disorder (MDD). Although accumulating efforts have …
pathophysiology of major depressive disorder (MDD). Although accumulating efforts have …
Assessment of cognitive functions in animal models of schizophrenia
A Nikiforuk - Pharmacological Reports, 2018 - Elsevier
Impaired cognitive functioning is recognized as an integral feature of schizophrenia. These
deficits have emerged not only as an important predictor of clinical and social outcomes but …
deficits have emerged not only as an important predictor of clinical and social outcomes but …