Ageing is accompanied by 2–4-fold increases in plasma/serum levels of inflammatory
mediators such as cytokines and acute phase proteins. A wide range of factors seems to …

Neuroinflammatory processes are a central feature of Alzheimer's disease (AD) in which
microglia are over-activated, resulting in the increased production of pro-inflammatory …

Almost a quarter of a century ago, interleukin-6 (IL-6) was discovered as an inflammatory
cytokine involved in B cell differentiation. Today, IL-6 is recognized to be a highly versatile …

In this paper, we review data of recent literature on the distribution in centenarians of
candidate germ-line polymorphisms that likely affect the individual chance to reach the …

Background: Neuroinflammation plays an important role in Alzheimer's disease (AD). During
this process, activated microglia release pro-inflammatory cytokines such as interleukin (IL) …

In the pathogenesis of Alzheimer disease (AD), it has been proposed that the anti-
inflammatory interleukins such as IL-10 regulate β-amyloid-induced microglial inflammatory …

Genetic factors have a variable impact on Alzheimer's Disease (AD), ranging from familial
forms that are transmitted in an autosomal dominant fashion to sporadic AD, where a …

Old-age survival has improved substantially since 1950 in developed countries. As a result
the number of octogenarians has increased four-fold, the number of nonagenarians eight …

Introduction 3. Immune system and aging 3.1. IL-6 and aging 3.1. 1. IL-6 structure and
function 3.1. 2. IL-6 receptor: structure and function 3.1. 3. IL-6 and “normal” aging 3.1. 4. IL …

Background: Vascular dementia (VaD) is the second most common type of dementia. So far,
little is known about the contribution of genetic polymorphisms to the risk of VaD. Many …