Chromosome positioning in the interphase nucleus
LA Parada, T Misteli - Trends in cell biology, 2002 - cell.com
Chromosomes occupy distinct territories in the interphase cell nucleus. These chromosome
territories are non-randomly arranged within the nuclear space. We are only just uncovering …
territories are non-randomly arranged within the nuclear space. We are only just uncovering …
Half a century of “the nuclear matrix”
T Pederson - Molecular biology of the cell, 2000 - Am Soc Cell Biol
A cell fraction that would today be termed “the nuclear matrix” was first described and
patented in 1948 by Russian investigators. In 1974 this fraction was rediscovered and …
patented in 1948 by Russian investigators. In 1974 this fraction was rediscovered and …
Quantitative imaging of transcription in living Drosophila embryos links polymerase activity to patterning
Spatiotemporal patterns of gene expression are fundamental to every developmental
program. The resulting macroscopic domains have been mainly characterized by their levels …
program. The resulting macroscopic domains have been mainly characterized by their levels …
[HTML][HTML] Precise developmental gene expression arises from globally stochastic transcriptional activity
Early embryonic patterning events are strikingly precise, a fact that appears incompatible
with the stochastic gene expression observed across phyla. Using single-molecule mRNA …
with the stochastic gene expression observed across phyla. Using single-molecule mRNA …
Cell cycle heterogeneity directs the timing of neural stem cell activation from quiescence
Quiescent stem cells in adult tissues can be activated for homeostasis or repair. Neural stem
cells (NSCs) in Drosophila are reactivated from quiescence in response to nutrition by the …
cells (NSCs) in Drosophila are reactivated from quiescence in response to nutrition by the …
A Balbiani body and the fusome mediate mitochondrial inheritance duringDrosophila oogenesis
RT Cox, AC Spradling - 2003 - journals.biologists.com
Maternally inherited mitochondria and other cytoplasmic organelles play essential roles
supporting the development of early embryos and their germ cells. Using methods that …
supporting the development of early embryos and their germ cells. Using methods that …
[HTML][HTML] Chromosomal dynamics at the Shh locus: limb bud-specific differential regulation of competence and active transcription
T Amano, T Sagai, H Tanabe, Y Mizushina… - Developmental cell, 2009 - cell.com
The expression of Sonic hedgehog (Shh) in mouse limb buds is regulated by a long-range
enhancer 1 Mb upstream of the Shh promoter. We used 3D-FISH and chromosome …
enhancer 1 Mb upstream of the Shh promoter. We used 3D-FISH and chromosome …
Splicing of oskar RNA in the nucleus is coupled to its cytoplasmic localization
O Hachet, A Ephrussi - Nature, 2004 - nature.com
Abstract oskar messenger RNA localization at the posterior pole of the Drosophila oocyte is
essential for germline and abdomen formation in the future embryo,. The nuclear shuttling …
essential for germline and abdomen formation in the future embryo,. The nuclear shuttling …
Multiplex Detection of RNA Expression in Drosophila Embryos
D Kosman, CM Mizutani, D Lemons, WG Cox… - Science, 2004 - science.org
We present a fluorescence-based, multiplex in situ hybridization method that permits the
simultaneous detection of five differently labeled antisense RNA probes and up to seven …
simultaneous detection of five differently labeled antisense RNA probes and up to seven …
Cup is an eIF4E binding protein required for both the translational repression of oskar and the recruitment of Barentsz
JE Wilhelm, M Hilton, Q Amos, WJ Henzel - The Journal of cell biology, 2003 - rupress.org
In Drosophila oocytes, precise localization of the posterior determinant, Oskar, is required for
posterior patterning. This precision is accomplished by a localization-dependent …
posterior patterning. This precision is accomplished by a localization-dependent …