The hepatitis C virus (HCV) persists in the majority of infected individuals and is a significant
cause of human illness and death globally. Recent studies have yielded important insights …

The hepatitis C virus (HCV) is a remarkably successful pathogen, establishing persistent
infection in more than two-thirds of those who contract it. Its success is related to its abilities …

Hepatitis C Virus (HCV) infection is a global public health problem affecting over 160 million
individuals worldwide. Its symptoms include chronic hepatitis, liver cirrhosis and …

BACKGROUND & AIMS: Dendritic cells (DCs) trigger adaptive immune responses and are
an important source of antiviral cytokines. In hepatitis C virus (HCV) infection DC function is …

The majority of individuals who become acutely infected with hepatitis C virus (HCV)
develop chronic infection and suffer from progressive liver damage while approximately …

As interferon/ribavirin-based standard therapy is curative in only about half of HCV patients,
there remains an important need for alternatives including vaccines. The novel peptide …

Plasmacytoid dendritic cells (pDCs) are the professional type I interferon (IFN)-producing
cells, and upon activation they traffic to lymph organs, where they bridge innate and …

Hepatitis C virus (HCV) induces persistent infection and causes chronic liver disease in most
infected patients. Vigorous HCV-specific CD4+ and CD8+ T cell responses against HCV …

Hepatitis C virus (HCV)-specific T-cell responses are rarely detected in peripheral blood,
especially in the presence of human immunodeficiency virus (HIV) coinfection. Based on …

Liver cirrhosis and hepatocellular carcinoma secondary to chronic hepatitis C virus (HCV)
infection requiring transplantation represents a significant public health problem. The most …