Autophagy is a powerful tool that host cells use to defend against viral infection. Double-
membrane vesicles, termed autophagosomes, deliver trapped viral cargo to the lysosome …

Autophagy is a fundamental eukaryotic pathway that has multiple effects on immunity.
Autophagy is induced by pattern recognition receptors and, through autophagic adaptors, it …

BCL-2 family proteins are the regulators of apoptosis, but also have other functions. This
family of interacting partners includes inhibitors and inducers of cell death. Together they …

Beclin 1, the mammalian orthologue of yeast Atg6, has a central role in autophagy, a
process of programmed cell survival, which is increased during periods of cell stress and …

An increasing body of research on autophagy provides overwhelming evidence for its
connection to diverse biological functions and human diseases. Beclin 1, the first …

Phagocytosis controls CNS homeostasis by facilitating the removal of unwanted cellular
debris. Accordingly, impairments in different receptors or proteins involved in phagocytosis …

The mammalian ortholog of yeast Atg6/Vps30, Beclin 1, is an essential autophagy protein
that has been linked to diverse biological processes, including immunity, development …

The accumulation of amyloid-β-containing neuritic plaques and intracellular tau protein
tangles are key histopathological hallmarks of Alzheimer's disease (AD). This type of …

Autophagy represents an intracellular degradation process which is involved in both cellular
homeostasis and disease settings. In the last two decades, the molecular machinery …

Peptide-based covalent probes can target shallow protein surfaces not typically addressable
using small molecules, yet there is a need for versatile approaches to convert native peptide …