Noncoding RNA therapeutics—challenges and potential solutions

M Winkle, SM El-Daly, M Fabbri, GA Calin - Nature reviews Drug …, 2021 - nature.com
Therapeutic targeting of noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and
long noncoding RNAs (lncRNAs), represents an attractive approach for the treatment of …

RNAi-based therapeutics and tumor targeted delivery in cancer

G Kara, GA Calin, B Ozpolat - Advanced drug delivery reviews, 2022 - Elsevier
Over the past decade, non-coding RNA-based therapeutics have proven as a great potential
for the development of targeted therapies for cancer and other diseases. The discovery of …

Novel nanomedicines to overcome cancer multidrug resistance

Z Su, S Dong, SC Zhao, K Liu, Y Tan, X Jiang… - Drug Resistance …, 2021 - Elsevier
Chemotherapy remains a powerful tool to eliminate malignant cells. However, the efficacy of
chemotherapy is compromised by the frequent emergence of intrinsic and acquired …

[HTML][HTML] Silica nanoparticles: A review of their safety and current strategies to overcome biological barriers

TI Janjua, Y Cao, F Kleitz, M Linden, C Yu… - Advanced Drug Delivery …, 2023 - Elsevier
Silica nanoparticles (SNP) have gained tremendous attention in the recent decades. They
have been used in many different biomedical fields including diagnosis, biosensing and …

Nanoparticles: From synthesis to applications and beyond

A Selmani, D Kovačević, K Bohinc - Advances in colloid and interface …, 2022 - Elsevier
In modern-day research, nanoparticles (size< 100 nm) are an indispensable tool for various
applications, especially in the field of biomedicine. Although enormous efforts have been …

Biomaterial-assisted biotherapy: A brief review of biomaterials used in drug delivery, vaccine development, gene therapy, and stem cell therapy

X Han, A Alu, H Liu, Y Shi, X Wei, L Cai, Y Wei - Bioactive Materials, 2022 - Elsevier
Biotherapy has recently become a hotspot research topic with encouraging prospects in
various fields due to a wide range of treatments applications, as demonstrated in preclinical …

Drug delivery of natural products through nanocarriers for effective breast cancer therapy: A comprehensive review of literature

KM Yap, M Sekar, S Fuloria, YS Wu… - International Journal …, 2021 - Taylor & Francis
Despite recent advances in the diagnosis and treatment of breast cancer (BC), it remains a
global health issue affecting millions of women annually. Poor prognosis in BC patients is …

The progress and perspective of strategies to improve tumor penetration of nanomedicines

J Hu, X Yuan, F Wang, H Gao, X Liu, W Zhang - Chinese Chemical Letters, 2021 - Elsevier
Tumor penetration is important for effectively tumor targeting drug delivery. Recently, many
researches are published to overcome the barriers that restrict tumor penetration and …

[HTML][HTML] Gene therapy in cancer treatment: why go nano?

C Roma-Rodrigues, L Rivas-García, PV Baptista… - Pharmaceutics, 2020 - mdpi.com
The proposal of gene therapy to tackle cancer development has been instrumental for the
development of novel approaches and strategies to fight this disease, but the efficacy of the …

Nanoparticle drug delivery systems for synergistic delivery of tumor therapy

D Chen, X Liu, X Lu, J Tian - Frontiers in Pharmacology, 2023 - frontiersin.org
Nanoparticle drug delivery systems have proved anti-tumor effects; however, they are not
widely used in tumor therapy due to insufficient ability to target specific sites, multidrug …