Novel targets to arrest neurodegeneration in several dementing conditions involving
misfolded protein accumulations may be found in the diverse signaling pathways of the …

One evident hallmark of Alzheimer's disease (AD) is the irregular accumulation of proteins
due to changes in proteostasis involving endoplasmic reticulum (ER) stress. To alleviate ER …

Neurodegenerative disorders are significantly increasing in incidence as the age of the
global population continues to climb with improved life expectancy. At present, more than 30 …

Synaptic mitochondria are particularly vulnerable to physiological insults, and defects in
synaptic mitochondria are linked to early pathophysiology of Alzheimer's disease (AD) …

Mechanistic/mammalian target of rapamycin (mTOR) belongs to the phosphatidylinositol
kinase-related kinase (PIKK) family. mTOR signaling is required for the commencement of …

Small guanosine triphosphatases (GTPases) of the Ras superfamily are key regulators of
many key cellular events such as proliferation, differentiation, cell cycle regulation …

The G protein coupled receptors (GPCRs) have been considered as one of the largest
families of validated drug targets, which involve in almost overall physiological functions and …

The small GTPases from the Ras superfamily play crucial roles in basic cellular processes
during practically the entire process of neurodevelopment, including neurogenesis …

The small G-protein Rheb activates the mechanistic target of rapamycin complex 1
(mTORC1) in response to growth factor signals. mTORC1 is a master regulator of cellular …

Short-term memory dysfunction is a key early feature of Alzheimer's disease (AD).
Psychiatric patients may be at higher risk for memory dysfunction and subsequent AD due to …