Significant progress has been made in the understanding of lung cancer biology, due in
large part to advancement in the understanding of tumor biology and pathogenesis …

Abstract The 2015 World Health Organization (WHO) Classification of Tumors of the Lung,
Pleura, Thymus and Heart has just been published with numerous important changes from …

Remarkable progress in molecular analyses has improved our understanding of the
evolution of cancer cells toward immune escape,,,–. However, the spatial configurations of …

The new International Association for the Study of Lung Cancer/American Thoracic
Society/European Respiratory Society lung adenocarcinoma classification provides, for the …

Lung cancer is the leading cause of cancer-related deaths worldwide. Next to
adenocarcinoma, squamous cell carcinoma (SCC) of the lung is the most frequent histologic …

Purpose: There is persistent controversy as to whether EGFR and KRAS mutations occur in
pulmonary squamous cell carcinoma (SQCC). We hypothesized that the reported variability …

The last decade has seen significant advances in our understanding of lung cancer biology
and management. Identification of key driver events in lung carcinogenesis has contributed …

Neuroendocrine neoplasms (NENs) of the lung encompass neuroendocrine tumors (NETs)
composed of typical (TC) and atypical (AC) carcinoids and full-fledged carcinomas (NECs) …

This study aimed at challenging pulmonary large cell carcinoma (LLC) as tumor entity and
defining different subgroups according to immunohistochemical and molecular features …

Abstract Exosomes are nano-sized (20–100 nm) vesicles released by a variety of cells and
are generated within the endosomal system or at the plasma membrane. There is emerging …