For many years, the laboratory mouse has been the favored model organism to study
mammalian development, biology and disease. Among its advantages for these studies are …

Neurodegeneration mediates neurological disability in inflammatory demyelinating diseases
of the CNS. The role of innate immune cells in mediating this damage has remained …

Differential artery-vein (AV) analysis is essential for retinal study, disease detection, and
treatment assessment. This study is to characterize vascular reflectance profiles and blood …

Retinal aging has been recognized as a significant risk factor for various retinal disorders,
including diabetic retinopathy, age-related macular degeneration, and glaucoma, following …

We searched a database of single-gene knockout (KO) mice produced by the International
Mouse Phenotyping Consortium (IMPC) to identify candidate ciliopathy genes. We first …

Retinal degeneration is a kind of neurodegeneration characterized by progressive neuronal
death and dysfunction of retinal pigment epithelium (RPE) cells, leading to permanent visual …

During development, neurons generate excess processes which are then eliminated in
concert with circuit maturation. C1q is the initiating protein in the complement cascade and …

Fine-scale molecular architecture is critical for nervous system and other biological
functions. Methods to visualize these nanoscale structures would benefit from enhanced …

Neuron function relies on and instructs the development and precise organization of
neurovascular units that in turn support circuit activity. However, our understanding of the …

Ciliary neurotrophic factor (CNTF) has been tested in clinical trials for human retinal
degeneration due to its potent neuroprotective effects in various animal models. To decipher …