Endogenous glucocorticoids are crucial to various physiological processes, including
metabolism, development and inflammation. Since 1948, synthetic glucocorticoids have …

Animals receive environmental stimuli from neural signals in order to produce hormones that
control immune responses. Glucocorticoids (GCs) are a group of steroid hormones …

The disruption of blood–brain barrier (BBB) for multiple sclerosis (MS) pathogenesis has a
double effect: early on during the onset of the immune attack and later for the CNS self …

Multiple sclerosis (MS) is a chronic debilitating disease of the central nervous system
primarily mediated by T lymphocytes with specificity to neuronal antigens in genetically …

Since the discovery of glucocorticoids in the 1940s and the recognition of their anti-
inflammatory effects, they have been amongst the most widely used and effective treatments …

Despite exosome promise as endogenous drug delivery vehicles, the current understanding
of exosome may be insufficient to develop their various applications. Here we synthesized …

In response to physiological and psychogenic stressors, the hypothalamic–pituitary–adrenal
(HPA) axis orchestrates the systemic release of glucocorticoids (GCs). By virtue of nearly …

Psychological stress has adverse effects on various human diseases, including those of the
cardiovascular system. However, the mechanisms by which stress influences disease …

For more than 70 years, glucocorticoids (GCs) have been a powerful and affordable
treatment option for inflammatory diseases. However, their benefits do not come without a …

Members of the nuclear receptor superfamily of ligand-dependent transcription factors
regulate diverse aspects of immunity and inflammation by both positively and negatively …