Pro-resolving lipid mediators: regulators of inflammation, metabolism and kidney function
Obesity, diabetes mellitus, hypertension and cardiovascular disease are risk factors for
chronic kidney disease (CKD) and kidney failure. Chronic, low-grade inflammation is …
chronic kidney disease (CKD) and kidney failure. Chronic, low-grade inflammation is …
The impact of insulin resistance on the kidney and vasculature
F Artunc, E Schleicher, C Weigert, A Fritsche… - Nature Reviews …, 2016 - nature.com
Insulin resistance is a systemic disorder that affects many organs and insulin-regulated
pathways. The disorder is characterized by a reduced action of insulin despite increased …
pathways. The disorder is characterized by a reduced action of insulin despite increased …
Acute kidney injury and progression of diabetic kidney disease
SMW Yu, JV Bonventre - Advances in chronic kidney disease, 2018 - Elsevier
Diabetic kidney disease, commonly termed diabetic nephropathy (DN), is the most common
cause of end-stage kidney disease (ESKD) worldwide. The characteristic histopathology of …
cause of end-stage kidney disease (ESKD) worldwide. The characteristic histopathology of …
Insulin signaling to the glomerular podocyte is critical for normal kidney function
Diabetic nephropathy (DN) is the leading cause of renal failure in the world. It is
characterized by albuminuria and abnormal glomerular function and is considered a …
characterized by albuminuria and abnormal glomerular function and is considered a …
[HTML][HTML] Proteinuria in diabetic kidney disease: a mechanistic viewpoint
JA Jefferson, SJ Shankland, RH Pichler - Kidney international, 2008 - Elsevier
Proteinuria is the hallmark of diabetic kidney disease (DKD) and is an independent risk
factor for both renal disease progression, and cardiovascular disease. Although the …
factor for both renal disease progression, and cardiovascular disease. Although the …
Diabetes mellitus, a complex and heterogeneous disease, and the role of insulin resistance as a determinant of diabetic kidney disease
J Karalliedde, L Gnudi - Nephrology dialysis transplantation, 2016 - academic.oup.com
Diabetes mellitus (DM) is increasingly recognized as a heterogeneous condition. The
individualization of care and treatment necessitates an understanding of the individual …
individualization of care and treatment necessitates an understanding of the individual …
Podocytes: the weakest link in diabetic kidney disease?
JS Lin, K Susztak - Current diabetes reports, 2016 - Springer
Diabetes is increasing in prevalence and is the leading cause of end-stage renal disease in
the United States. Diabetic kidney disease is considered a proteinuric glomerular disease …
the United States. Diabetic kidney disease is considered a proteinuric glomerular disease …
Cell biology of diabetic nephropathy: roles of endothelial cells, tubulointerstitial cells and podocytes
Y Maezawa, M Takemoto… - Journal of diabetes …, 2015 - Wiley Online Library
Diabetic nephropathy is the major cause of end‐stage renal failure throughout the world in
both developed and developing countries. Diabetes affects all cell types of the kidney …
both developed and developing countries. Diabetes affects all cell types of the kidney …
Nephrin signaling in the podocyte: an updated view of signal regulation at the slit diaphragm and beyond
Podocytes are a major component of the glomerular blood filtration barrier, and alterations to
the morphology of their unique actin-based foot processes (FP) are a common feature of …
the morphology of their unique actin-based foot processes (FP) are a common feature of …
Dysregulated nephrin in diabetic nephropathy of type 2 diabetes: a cross sectional study
B Jim, M Ghanta, A Qipo, Y Fan, PY Chuang… - PloS one, 2012 - journals.plos.org
Background Podocyte specific proteins are dysregulated in diabetic nephropathy, though
the extent of their expression loss is not identical and may be subject to different regulatory …
the extent of their expression loss is not identical and may be subject to different regulatory …