Transient receptor potential vanilloid type 4 (TRPV4) is a calcium-permeable nonselective
cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol …

Exercise training results in beneficial adaptations to numerous tissues and offers protection
against metabolic disorders including obesity and type 2 diabetes. Multiple studies have …

Key points Mice are commonly housed at room temperatures below their thermoneutral
zone meaning they are exposed to chronic thermal stress. Endurance exercise induces …

Objective Growth differentiation factor (GDF)-15 is implicated in regulation of metabolism
and circulating GDF15 increases in response to exercise. The source and regulation of the …

ABSTRACT MACPHERSON, REK, JS HUBER, S. FRENDO-CUMBO, JA SIMPSON, and DC
WRIGHT. Adipose Tissue Insulin Action and IL-6 Signaling after Exercise in Obese Mice …

Obesity and type 2 diabetes are significant risk factors in the development of
neurodegenerative diseases, such as Alzheimer's disease. A variety of cellular mechanisms …

Physical exercise is one of the most important factors improving quality of life, but it is not
feasible for patients with morbidity or limited mobility. Most previous studies focused on high …

Sepsis is a systemic inflammatory response to infection, with no preventative strategies. In
this study, we identify a role for habitual physical activity in the prevention of adipose tissue …

Physical activity and its sustained and purposeful performance—exercise—promote a broad
and diverse set of metabolic and cardiovascular health benefits. Regular exercise is the …

Key points Mammals defend against cold‐induced reductions in body temperature through
both shivering and non‐shivering thermogenesis. The activation of non‐shivering …