Background Non‐alcoholic fatty liver disease (NAFLD) is currently conceptualised as a
clinical spectrum that results from a 'multiple‐hit'process which begins with simple steatosis …

Constitutive activation of the Hedgehog (Hh) signaling pathway is associated with increased
risk of developing several malignancies. The biological and pathogenic importance of Hh …

Hepatitis B virus (HBV)-specific CD8 T cells are functionally exhausted in chronic hepatitis B
infection, and this condition can be corrected only partially through the modulation of …

Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal disease of unknown etiology
and uncertain pathogenic mechanisms. Recent studies indicate that the pathogenesis of the …

Hedgehog (HH) and TGF-β signals control various aspects of embryonic development and
cancer progression. While their canonical signal transduction cascades have been well …

Abstract Purpose: Basal cell carcinomas (BCCs) are tumors ignored by immune
surveillance. Activated Hedgehog (Hh) signaling within primary cilia is a key driver in the …

Host responses to tumor cells include tumor suppressing or promoting mechanisms. We
sought to detail the effect of Hedgehog (Hh) pathway inhibition on the composition of the …

Targeting the hedgehog (HH) pathway to treat aggressive cancers of the brain, breast,
pancreas, and prostate has been ongoing for decades. Gli gene amplifications have been …

The Hedgehog (Hh) signaling pathway is pervasively involved in human malignancies,
making it an effective target for cancer treatment for decades. In addition to its direct role in …

Allergic diseases, characterized by a broad spectrum of clinical manifestations and
symptoms, encompass a significant category of IgE-mediated atopic disorders, including …