Cerebral small vessel disease (CSVD) is composed of several diseases affecting the small
arteries, arterioles, venules, and capillaries of the brain, and refers to several pathological …

Oxygen (O 2) availability is a key factor regulating microbiota composition and the
homeostatic function of cells in the intestinal mucosa of vertebrates. Microbiota-derived …

The transcription factors Olig2 and Sox10 jointly define oligodendroglial identity. Because of
their continuous presence during development and in the differentiated state they shape the …

Cerebral small vessel disease is characterised by decreased cerebral blood flow and blood–
brain barrier impairments which play a key role in the development of white matter lesions …

Exposure to environmental chemicals can impair neurodevelopment, and oligodendrocytes
may be particularly vulnerable, as their development extends from gestation into adulthood …

Myelin sheath, formed by oligodendrocytes (OLs) in the central nervous system (CNS) and
Schwann cells in periphery, plays a critical role in supporting neuronal functions. OLs …

The cellular microenvironment, together with intrinsic regulators, shapes stem cell identity
and differentiation capacity. Mammalian early embryos are exposed to hypoxia in vivo and …

Oligodendrocytes are specialized cells that confer neuronal myelination in the central
nervous system. Leukodystrophies associated with oligodendrocyte deficits and …

Interleukin 17 (IL-17) is a signature cytokine of Th17 cells. IL-17 level is significantly
increased in inflammatory conditions of the CNS, including but not limited to post-stroke and …

Early B cell factor 1 (EBF1) is a transcriptional factor with a variety of roles in cell
differentiation and metabolism. However, the functional roles of EBF1 in tumorigenesis …