Genome chaos: Creating new genomic information essential for cancer macroevolution
Cancer research has traditionally focused on the characterization of individual molecular
mechanisms that can contribute to cancer. Due to the multiple levels of genomic and non …
mechanisms that can contribute to cancer. Due to the multiple levels of genomic and non …
Single cell metabolomics using mass spectrometry: Techniques and data analysis
Mass spectrometry (MS) based techniques are gaining popularity for metabolomics research
due to their high sensitivity, wide detection range, and capability of molecular identification …
due to their high sensitivity, wide detection range, and capability of molecular identification …
Single-cell sequencing reveals karyotype heterogeneity in murine and human malignancies
B Bakker, A Taudt, ME Belderbos, D Porubsky… - Genome biology, 2016 - Springer
Background Chromosome instability leads to aneuploidy, a state in which cells have
abnormal numbers of chromosomes, and is found in two out of three cancers. In a …
abnormal numbers of chromosomes, and is found in two out of three cancers. In a …
Micronuclei and genome chaos: changing the system inheritance
CJ Ye, Z Sharpe, S Alemara, S Mackenzie, G Liu… - Genes, 2019 - mdpi.com
Micronuclei research has regained its popularity due to the realization that genome chaos, a
rapid and massive genome re-organization under stress, represents a major common …
rapid and massive genome re-organization under stress, represents a major common …
Genome chaos: survival strategy during crisis
G Liu, J Stevens, S Horne, B Abdallah, K Ye, S Bremer… - Cell Cycle, 2014 - Taylor & Francis
Genome chaos, a process of complex, rapid genome re-organization, results in the
formation of chaotic genomes, which is followed by the potential to establish stable …
formation of chaotic genomes, which is followed by the potential to establish stable …
Cell population heterogeneity and evolution towards drug resistance in cancer: biological and mathematical assessment, theoretical treatment optimisation
Background Drug-induced drug resistance in cancer has been attributed to diverse
biological mechanisms at the individual cell or cell population scale, relying on …
biological mechanisms at the individual cell or cell population scale, relying on …
Ontogenetic and pathogenetic views on somatic chromosomal mosaicism
Intercellular karyotypic variability has been a focus of genetic research for more than 50
years. It has been repeatedly shown that chromosome heterogeneity manifesting as …
years. It has been repeatedly shown that chromosome heterogeneity manifesting as …
Origins and consequences of chromosomal instability: From cellular adaptation to genome chaos-mediated system survival
CJ Ye, Z Sharpe, HH Heng - Genes, 2020 - mdpi.com
When discussing chromosomal instability, most of the literature focuses on the
characterization of individual molecular mechanisms. These studies search for genomic and …
characterization of individual molecular mechanisms. These studies search for genomic and …
Evolutionary mechanism unifies the hallmarks of cancer
The basis for the gene mutation theory of cancer that dominates current molecular cancer
research consists of: the belief that gene‐level aberrations such as mutations are the main …
research consists of: the belief that gene‐level aberrations such as mutations are the main …
Tracking the evolution of cancer cell populations through the mathematical lens of phenotype-structured equations
Background A thorough understanding of the ecological and evolutionary mechanisms that
drive the phenotypic evolution of neoplastic cells is a timely and key challenge for the cancer …
drive the phenotypic evolution of neoplastic cells is a timely and key challenge for the cancer …