Complement evasion strategies of viruses: an overview
Being a major first line of immune defense, the complement system keeps a constant vigil
against viruses. Its ability to recognize large panoply of viruses and virus-infected cells, and …
against viruses. Its ability to recognize large panoply of viruses and virus-infected cells, and …
[HTML][HTML] Complement component C3: a structural perspective and potential therapeutic implications
As the most abundant component of the complement system, C3 and its proteolytic
derivatives serve essential roles in the function of all three complement pathways. Central to …
derivatives serve essential roles in the function of all three complement pathways. Central to …
Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses
The complement system labels microbes and host debris for clearance. Degradation of
surface-bound C3b is pivotal to direct immune responses and protect host cells. How the …
surface-bound C3b is pivotal to direct immune responses and protect host cells. How the …
Regulators of complement activity mediate inhibitory mechanisms through a common C3b‐binding mode
Regulators of complement activation (RCA) inhibit complement‐induced immune responses
on healthy host tissues. We present crystal structures of human RCA (MCP, DAF, and CR 1) …
on healthy host tissues. We present crystal structures of human RCA (MCP, DAF, and CR 1) …
The imitation game: a viral strategy to subvert the complement system
Viruses are obligate parasites of cellular hosts and therefore are constantly confronted with
the host immune system. Evasion of innate immunity mechanisms by viruses is paramount …
the host immune system. Evasion of innate immunity mechanisms by viruses is paramount …
Spatially conserved motifs in complement control protein domains determine functionality in regulators of complement activation-family proteins
H Ojha, P Ghosh, H Singh Panwar, R Shende… - Communications …, 2019 - nature.com
Regulation of complement activation in the host cells is mediated primarily by the regulators
of complement activation (RCA) family proteins that are formed by tandemly repeating …
of complement activation (RCA) family proteins that are formed by tandemly repeating …
Virus-encoded complement regulators: current status
Viruses require a host for replication and survival and hence are subjected to host
immunological pressures. The complement system, a crucial first response of the host …
immunological pressures. The complement system, a crucial first response of the host …
Characterization of genetic predisposition and autoantibody profile in atypical haemolytic–uraemic syndrome
BS Gurjar, T Manikanta Sriharsha, A Bhasym… - …, 2018 - Wiley Online Library
We previously reported that Indian paediatric patients with atypical haemolytic–uraemic
syndrome (aHUS) showed high frequencies of anti‐complement factor H (FH) …
syndrome (aHUS) showed high frequencies of anti‐complement factor H (FH) …
How novel structures inform understanding of complement function
During the last decade, the complement field has experienced outstanding advancements in
the mechanistic understanding of how complement activators are recognized, what C3 …
the mechanistic understanding of how complement activators are recognized, what C3 …
Molecular engineering of an efficient four-domain DAF-MCP chimera reveals the presence of functional modularity in RCA proteins
The complement system is highly efficient in targeting pathogens, but lack of its apposite
regulation results in host-cell damage, which is linked to diseases. Thus, complement …
regulation results in host-cell damage, which is linked to diseases. Thus, complement …