Cystathionine-β-synthase: molecular regulation and pharmacological inhibition

K Zuhra, F Augsburger, T Majtan, C Szabo - Biomolecules, 2020 - mdpi.com
Cystathionine-β-synthase (CBS), the first (and rate-limiting) enzyme in the transsulfuration
pathway, is an important mammalian enzyme in health and disease. Its biochemical …

Metallodendrimers as a promising tool in the biomedical field: An overview

NS del Olmo, R Carloni, P Ortega… - Advances in …, 2020 - Elsevier
Metallodendrimers have emerged in recent years as promising strategies in biomedicine.
These molecules of nanometric size have attracted widespread attention, combining, in a …

Synthesis, characterization of Schiff base metal complexes with 1, 3 propanediamine as secondary chelates and their DNA binding, DNA cleavage, cytotoxicity …

M Pichandi, S Shanmugam - Journal of Molecular Structure, 2024 - Elsevier
A series of Cu (II), Co (II), Ni (II), and Zn (II) complexes were synthesised from ternary Schiff
base ligand (ts) and 1, 3-propanediamine (pda). These complexes were characterised using …

Self-assembled ruthenium (II) metallacycles and metallacages with imidazole-based ligands and their in vitro anticancer activity

Y Zhao, L Zhang, X Li, Y Shi, R Ding… - Proceedings of the …, 2019 - National Acad Sciences
Six tetranuclear rectangular metallacycles were synthesized via the [2+ 2] coordination-
driven self-assembly of imidazole-based ditopic donor 1, 4-bis (imidazole-1-yl) benzene and …

Synthesis, structural, and photophysical properties of pyrazolyl bis (pentafluorophenyl) boron complexes

AC Murali, P Pratakshya, P Patel, P Nayak… - New Journal of …, 2023 - pubs.rsc.org
Luminescent materials have garnered significant research interest due to their potential
applications in optoelectronics, sensing, and medical diagnostics. Within this context, tetra …

Induction of apoptosis and autophagy by ternary copper complex towards breast cancer cells

ZY Lee, CH Leong, KUL Lim, C Wong… - Anti-Cancer Agents …, 2022 - ingentaconnect.com
Background: Copper complex has been gaining much attention in anticancer research as a
targeted agent since cancer cells uptake more copper than non-cancerous cells. Our group …

Supramolecular assemblies involving unconventional non-covalent contacts in pyrazole-based coordination compounds of Co (II) and Cu (II) pyridinedicarboxylates …

D Dutta, P Sharma, RM Gomila, A Frontera… - Polyhedron, 2022 - Elsevier
Two coordination compounds of Co (II) and Cu (II) viz.[Co (2, 6-PDC)(Hdmpz) 3]· H 2 O (1)
and [Cu (2, 6-PDC)(Hdmpz) 2](2)(2, 6-PDC= 2, 6-pyridinedicarboxylate, Hdmpz= 3, 5 …

Ternary copper (Ii) complex induced apoptosis and cell cycle arrest in colorectal cancer cells

S Arikrishnan, JS Loh, XW Teo… - Anti-Cancer Agents …, 2022 - ingentaconnect.com
Background: The lack of specificity, severe side effects, and development of drug resistance
have largely limited the use of platinum-based compounds in cancer treatment. Therefore …

The role of cystathionine β-synthase in cancer

YW Wang, T Chu, XL Wang, YQ Fan, L Cao, YH Chen… - Cellular …, 2024 - Elsevier
Cystathionine β-synthase (CBS) occupies a key position as the initiating and rate-limiting
enzyme in the sulfur transfer pathway and plays a vital role in health and disease. CBS is …

Evaluation of antiproliferative palladium (II) complexes of synthetic bisdemethoxycurcumin towards in vitro cytotoxicity and molecular docking on DNA sequence

N Miklášová, P Herich, JC Dávila-Becerril… - Molecules, 2021 - mdpi.com
Metallodrugs form a large family of therapeutic agents against cancer, among which is
cisplatin, a paradigmatic member. Therapeutic resistance and undesired side effects to Pt (II) …