Bones provide essential functions and are sites of unique biochemistry and specialized
cells, but can also be sites of disease. The treatment of bone disorders and neoplasia has …

Rhenium-188 (188Re) is a high energy beta-emitting radioisotope with a short 16.9 h
physical half-life, which has been shown to be a very attractive candidate for use in …

Although bone tissues possess an intrinsic capacity for repair, there are cases where bone
healing is either impaired or insufficient, such as fracture non-union, osteoporosis …

The systemic administration of drugs to treat bone diseases is often associated with poor
uptake of the drug in the targeted tissue, potential systemic toxicity and suboptimal efficacy …

Targeted radionuclide therapy has become increasingly prominent as a nuclear medicine
subspecialty. For many decades, treatment with radionuclides has been mainly restricted to …

The coordination between bone resorption and bone formation plays an essential role in
keeping the mass and microstructure integrity of the bone in a steady state. However, this …

Organophosphorous compounds have recently emerged as a powerful class of compounds
with widespread applications, such as in bioactive natural products, pharmaceuticals …

In recent years, radiometals have been successfully applied to medicine because of their
breadth of decay properties and increased production and availability. Bifunctional chelators …

Bone metastases, often a consequence of breast, prostate, and lung carcinomas, are
characterized by an increased bone turnover, which can be visualized by positron emission …

Precision oncology is being driven by rapid advances in novel diagnostics and therapeutic
interventions, with treatments targeted to the needs of individual patients on the basis of …