Treatment of fecal incontinence: state of the science summary for the National Institute of Diabetes and Digestive and Kidney Diseases workshop
WE Whitehead, SSC Rao, A Lowry… - Official journal of the …, 2015 - journals.lww.com
This is the second of a two-part summary of a National Institutes of Health conference on
fecal incontinence (FI) that summarizes current treatments and identifies research priorities …
fecal incontinence (FI) that summarizes current treatments and identifies research priorities …
BDNF augments rat internal anal sphincter smooth muscle tone via RhoA/ROCK signaling and nonadrenergic noncholinergic relaxation via increased NO release
Presently, there are no studies examining the neuromodulatory effects of brain-derived
neurotropic factor (BDNF) on the basal internal anal sphincter (IAS) tone and nonadrenergic …
neurotropic factor (BDNF) on the basal internal anal sphincter (IAS) tone and nonadrenergic …
Ca2+/calmodulin/MLCK pathway initiates, and RhoA/ROCK maintains, the internal anal sphincter smooth muscle tone
S Rattan - … Journal of Physiology-Gastrointestinal and Liver …, 2017 - journals.physiology.org
IT IS WELL KNOWN that smooth muscle contraction, whether spontaneous or following
pharmacological stimulation, occurs in two phases: the initial phasic followed by the tonic …
pharmacological stimulation, occurs in two phases: the initial phasic followed by the tonic …
Aging-associated changes in microRNA expression profile of internal anal sphincter smooth muscle: Role of microRNA-133a
A comprehensive genomic and proteomic, computational, and physiological approach was
employed to examine the (previously unexplored) role of microRNAs (miRNAs) as …
employed to examine the (previously unexplored) role of microRNAs (miRNAs) as …
Activation of coronary arteriolar PKCβ2 impairs endothelial NO-mediated vasodilation: role of JNK/Rho kinase signaling and xanthine oxidase activation
Protein kinase C (PKC) activation can evoke vasoconstriction and contribute to coronary
disease. However, it is unclear whether PKC activation, without activating the contractile …
disease. However, it is unclear whether PKC activation, without activating the contractile …
In vivo magnetofection: a novel approach for targeted topical delivery of nucleic acids for rectoanal motility disorders
In these studies, we developed a novel approach of in vivo magnetofection for localized
delivery of nucleic acids such as micro-RNA-139-5p (miR-139-5p; which is known to target …
delivery of nucleic acids such as micro-RNA-139-5p (miR-139-5p; which is known to target …
An aligned nanofiber nerve conduit that inhibits painful traumatic neuroma formation through regulation of the RhoA/ROCK signaling pathway
X Zhou, B Zhao, K Poonit, W Weng, C Yao, C Sun… - Journal of …, 2019 - thejns.org
OBJECTIVE Traumatic neuromas represent a prevalent source of neuropathic pain. As of
yet, there has been no single treatment method that can guarantee permanent relief of …
yet, there has been no single treatment method that can guarantee permanent relief of …
Nature of extracellular signal that triggers RhoA/ROCK activation for the basal internal anal sphincter tone in humans
S Rattan, J Singh, S Kumar… - American Journal of …, 2015 - journals.physiology.org
The extracellular signal that triggers activation of rho-associated kinase (RhoA/ROCK), the
major molecular determinant of basal internal anal sphincter (IAS) smooth muscle tone, is …
major molecular determinant of basal internal anal sphincter (IAS) smooth muscle tone, is …
Regulation of spontaneous contractions in intact rat bladder strips and the effects of hydrogen peroxide
M Wang, N Xing, L Wu, WC Huang… - BioMed Research …, 2018 - Wiley Online Library
Enhanced spontaneous contractions are associated with overactive bladder. Elevated levels
of reactive oxygen species might contribute to enhanced spontaneous contractions. We …
of reactive oxygen species might contribute to enhanced spontaneous contractions. We …
Downregulation of thromboxane A2 and angiotensin II type 1 receptors associated with aging-related decrease in internal anal sphincter tone
Aging-associated decrease in internal anal sphincter (IAS) tone (AADI) is a major contributor
in the rectoanal incontinence (RI). To determine the pathogenesis of AADI, we investigated …
in the rectoanal incontinence (RI). To determine the pathogenesis of AADI, we investigated …