Pulmonary fibrosis: pathogenesis and therapeutic strategies
J Wang, K Li, D Hao, X Li, Y Zhu, H Yu, H Chen - MedComm, 2024 - Wiley Online Library
Pulmonary fibrosis (PF) is a chronic and progressive lung disease characterized by
extensive alterations of cellular fate and function and excessive accumulation of …
extensive alterations of cellular fate and function and excessive accumulation of …
[HTML][HTML] Tissue fibroblasts are versatile immune regulators: an evaluation of their impact on the aging process
A Salminen, K Kaarniranta, A Kauppinen - Ageing Research Reviews, 2024 - Elsevier
Fibroblasts are abundant stromal cells which not only control the integrity of extracellular
matrix (ECM) but also act as immune regulators. It is known that the structural cells within …
matrix (ECM) but also act as immune regulators. It is known that the structural cells within …
GLP-1R activation attenuates the progression of pulmonary fibrosis via disrupting NLRP3 inflammasome/PFKFB3-driven glycolysis interaction and histone lactylation
C Liu, Q Zhang, H Zhou, L Jin, C Liu, M Yang… - Journal of Translational …, 2024 - Springer
Background Pulmonary fibrosis is a serious interstitial lung disease with no viable treatment
except for lung transplantation. Glucagon-like peptide-1 receptor (GLP-1R), commonly …
except for lung transplantation. Glucagon-like peptide-1 receptor (GLP-1R), commonly …
Addition of polyphenols to drugs: the potential of controlling “inflammaging” and fibrosis in human senescent lung fibroblasts in vitro
MCX Godoy, GA Monteiro, BH Moraes… - International Journal of …, 2024 - mdpi.com
The combination of a polyphenol, quercetin, with dasatinib initiated clinical trials to evaluate
the safety and efficacy of senolytics in idiopathic pulmonary fibrosis, a lung disease …
the safety and efficacy of senolytics in idiopathic pulmonary fibrosis, a lung disease …
Tracking inflammation resolution signatures in lungs after SARS-CoV-2 omicron BA. 1 infection of K18-hACE2 mice
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes Coronavirus
Disease 2019 (COVID-19), which can result in severe disease, often characterised by a …
Disease 2019 (COVID-19), which can result in severe disease, often characterised by a …
Tetrandrine Alleviates Pulmonary Fibrosis by Modulating Lung Microbiota‐Derived Metabolism and Ameliorating Alveolar Epithelial Cell Senescence
J Zhuo, L Chu, D Liu, J Zhang, W Chen… - Phytotherapy …, 2024 - Wiley Online Library
Tetrandrine (TET) is a minimally toxic drug extracted from the root of Stephania tetrandra.
We previously demonstrated that TET could ameliorate pulmonary fibrosis (PF) by …
We previously demonstrated that TET could ameliorate pulmonary fibrosis (PF) by …
Deficiency and dysfunctional roles of natural killer T cells in patients with ARDS
KJ Park, TO Kim, YN Cho, HM Jin, YG Jo… - Frontiers in …, 2024 - frontiersin.org
Objective Acute respiratory distress syndrome (ARDS) presents a global health challenge,
characterized by significant morbidity and mortality. However, the role of natural killer T …
characterized by significant morbidity and mortality. However, the role of natural killer T …
Co-culture of human AT2 cells with fibroblasts reveals a MUC5B phenotype: insights from an organoid model
Y Yao, F Ritzmann, S Miethe, K Kattler-Lackes… - Molecular …, 2024 - Springer
Impaired interaction of fibroblasts with pneumocytes contributes to the progression of
chronic lung disease such as idiopathic pulmonary fibrosis (IPF). Mucin 5B (MUC5B) is …
chronic lung disease such as idiopathic pulmonary fibrosis (IPF). Mucin 5B (MUC5B) is …
[HTML][HTML] Protective effects of paeonol against cognitive impairment in lung diseases
Pulmonary inflammation may lead to neuroinflammation resulting in neurological
dysfunction, and it is associated with a variety of acute and chronic lung diseases. Paeonol …
dysfunction, and it is associated with a variety of acute and chronic lung diseases. Paeonol …
Pneumolysin-responsive liposomal platform for selective treatment of Streptococcus pneumoniae
E Watt, I Andriescu, EA Ho - Drug Delivery and Translational Research, 2024 - Springer
The bacterium Streptococcus pneumoniae has become a leading cause of meningitis,
sepsis, and bacterial pneumonia worldwide, with increased prevalence of antibiotic-resistant …
sepsis, and bacterial pneumonia worldwide, with increased prevalence of antibiotic-resistant …