To maintain iron homeostasis, fungi have to balance iron acquisition, storage, and utilization
to ensure sufficient supply and to avoid toxic excess of this essential trace element. As …

Sterols are a major component of eukaryotic cell membranes. For human fungal infections
caused by the filamentous fungus Aspergillus fumigatus, antifungal drugs that target sterol …

Successful treatment of aspergillosis caused by Aspergillus fumigatus is threatened by an
increasing incidence of drug resistance. This situation is further complicated by the finding …

The genus Aspergillus is ubiquitous in the environment and contains a number of species,
primarily A. fumigatus, that cause mold-associated disease in humans. Humans inhale …

The mitochondrial rhomboid protease PARL regulates mitophagy by balancing
intramembrane proteolysis of PINK1 and PGAM5. It has been implicated in the pathogenesis …

Environmental fungi are globally ubiquitous and human exposure is near universal.
However, relatively few fungal species are capable of infecting humans, and among fungi …

Hypoxic growth of fungi requires sterol regulatory element‐binding protein (SREBP)
transcription factors, and human opportunistic fungal pathogens require SREBP activation …

Rhomboids are conserved intramembrane serine proteases with widespread functions.
They were the earliest discovered members of the wider rhomboid-like superfamily of …

Aspergillus fumigatus isolates display significant heterogeneity in growth, virulence,
pathology, and inflammatory potential in multiple murine models of invasive aspergillosis …

Sterol regulatory element binding proteins (SREBPs) are conserved from yeast to
mammalian cells and function in the regulation of sterol homeostasis. In fungi, the SREBP …