Deciphering the cells of origin of squamous cell carcinomas
A Sanchez-Danes, C Blanpain - Nature Reviews Cancer, 2018 - nature.com
Squamous cell carcinomas (SCCs) are among the most prevalent human cancers. SCC
comprises a wide range of tumours originated from diverse anatomical locations that share …
comprises a wide range of tumours originated from diverse anatomical locations that share …
The developmental origin of brain tumours: a cellular and molecular framework
The development of the nervous system relies on the coordinated regulation of stem cell self-
renewal and differentiation. The discovery that brain tumours contain a subpopulation of …
renewal and differentiation. The discovery that brain tumours contain a subpopulation of …
N7-methylguanosine tRNA modification promotes esophageal squamous cell carcinoma tumorigenesis via the RPTOR/ULK1/autophagy axis
Mis-regulated RNA modifications promote the processing and translation of oncogenic
mRNAs to facilitate cancer progression, while the molecular mechanisms remain unclear …
mRNAs to facilitate cancer progression, while the molecular mechanisms remain unclear …
Mutant clones in normal epithelium outcompete and eliminate emerging tumours
Human epithelial tissues accumulate cancer-driver mutations with age,,,,,,,–, yet tumour
formation remains rare. The positive selection of these mutations suggests that they alter the …
formation remains rare. The positive selection of these mutations suggests that they alter the …
Spatial competition shapes the dynamic mutational landscape of normal esophageal epithelium
During aging, progenitor cells acquire mutations, which may generate clones that colonize
the surrounding tissue. By middle age, normal human tissues, including the esophageal …
the surrounding tissue. By middle age, normal human tissues, including the esophageal …
Organismal metabolism regulates the expansion of oncogenic PIK3CA mutant clones in normal esophagus
Oncogenic PIK3CA mutations generate large clones in aging human esophagus. Here we
investigate the behavior of Pik3ca mutant clones in the normal esophageal epithelium of …
investigate the behavior of Pik3ca mutant clones in the normal esophageal epithelium of …
Enhancement of TKI sensitivity in lung adenocarcinoma through m6A-dependent translational repression of Wnt signaling by circ-FBXW7
K Li, ZY Peng, R Wang, X Li, N Du, DP Liu, J Zhang… - Molecular Cancer, 2023 - Springer
Abstract Background Tyrosine kinase inhibitors (TKIs) that specifically target mutational
points in the EGFR gene have significantly reduced suffering and provided greater relief to …
points in the EGFR gene have significantly reduced suffering and provided greater relief to …
[HTML][HTML] Self-sustaining long-term 3D epithelioid cultures reveal drivers of clonal expansion in esophageal epithelium
Aging epithelia are colonized by somatic mutations, which are subjected to selection
influenced by intrinsic and extrinsic factors. The lack of suitable culture systems has slowed …
influenced by intrinsic and extrinsic factors. The lack of suitable culture systems has slowed …
Notch1 mutations drive clonal expansion in normal esophageal epithelium but impair tumor growth
NOTCH1 mutant clones occupy the majority of normal human esophagus by middle age but
are comparatively rare in esophageal cancers, suggesting NOTCH1 mutations drive clonal …
are comparatively rare in esophageal cancers, suggesting NOTCH1 mutations drive clonal …
Outcompeting p53-mutant cells in the normal esophagus by redox manipulation
As humans age, normal tissues, such as the esophageal epithelium, become a patchwork of
mutant clones. Some mutations are under positive selection, conferring a competitive …
mutant clones. Some mutations are under positive selection, conferring a competitive …