Importance Parkinson disease is the most common form of parkinsonism, a group of
neurological disorders with Parkinson disease–like movement problems such as rigidity …

Health data are increasingly being generated at a massive scale, at various levels of
phenotyping and from different types of resources. Concurrent with recent technological …

Several studies have confirmed the α-synuclein real-time quaking-induced conversion (RT-
QuIC) assay to have high sensitivity and specificity for Parkinson's disease. However …

Background Cluster algorithms are gaining in popularity in biomedical research due to their
compelling ability to identify discrete subgroups in data, and their increasing accessibility in …

Importance Clinical subtyping of Parkinson disease at diagnosis is useful in estimating
disease course and survival. Severity and rate of progression of neuropathologies are …

Background There are currently no treatments that stop or slow the progression of
Parkinson's disease (PD). Case–control genome‐wide association studies have identified …

Although Parkinson's disease (PD) is primarily a movement disorder, there are a range of
associated nonmotor symptoms, including cognitive impairment, depression and sleep …

Background Dementia is common in Parkinson's disease (PD) but measures that track
cognitive change in PD are lacking. Brain tissue iron accumulates with age and co-localises …

Sleep disturbances are common and a major source of disability in Parkinson's disease
(PD). Primary and secondary insomnia, rapid eye movement sleep behavior disorder (RDB) …

Background: In Parkinson's disease (PD), there is heterogeneity in the clinical presentation
and underlying biology. Research on PD subtypes aims to understand this heterogeneity …