Astrogliosis and sexually dimorphic neurodegeneration and microgliosis in the olfactory bulb in Parkinson's disease

A Flores-Cuadrado, D Saiz-Sanchez… - npj Parkinson's …, 2021 - nature.com
Hyposmia is prodromal, and male sex is a risk marker for an enhanced likelihood ratio of
Parkinson's disease. The literature regarding olfactory bulb volume reduction is …

Proteoform Analysis of the Human Olfactory System: A Window into Neurodegenerative Diseases

E Rusi, F Pennacchia, WA Ruqa, G Talarico, G Bruno… - Proteomes, 2024 - mdpi.com
Background: Very little is known about the proteome of the human olfactory system and how
diseases associated with olfactory dysfunctions can affect it. With this review, we try to …

Transcriptomic insights into the response of the olfactory bulb to selenium treatment in a mouse model of Alzheimer's disease

R Zheng, ZH Zhang, YX Zhao, C Chen, SZ Jia… - International journal of …, 2019 - mdpi.com
Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by the
presence of extracellular senile plaques primarily composed of Aβ peptides and intracellular …

Proteomic Analysis of Human Breast Cancer MCF-7 Cells to Identify Cellular Targets of the Anticancer Pigment OR3 from Streptomyces coelicolor JUACT03

M Dammalli, VK Nadumane - Applied Biochemistry and Biotechnology, 2023 - Springer
Search for ideal compounds with known pathways of anticancer mechanism is still a priority
research focus for cancer, as it continues to be a major health challenge across the globe …

Proteomics of the human olfactory tract

M Dammalli, G Dey, M Kumar… - OMICS: A Journal of …, 2018 - liebertpub.com
Human olfactory tract plays a fundamental role in health and disease. Proteomic analysis of
the olfactory tract therefore bears fundamental importance for integrative biology and clinical …

Sensory modulation in mental health practice

D Hitch, C Wilson, A Hillman - Mental Health Practice, 2024 - journals.rcni.com
Sensory modulation approaches have become increasingly prevalent in Australian mental
health practice over the past few years, but their use in UK mental health services remains in …

Smelling the dark proteome: functional characterization of PITH domain-containing protein 1 (C1orf128) in olfactory metabolism

M Lachén-Montes, N Mendizuri, K Ausín… - Journal of Proteome …, 2020 - ACS Publications
The Human Proteome Project (HPP) consortium aims to functionally characterize the dark
proteome. On the basis of the relevance of olfaction in early neurodegeneration, we have …

Neuronal and glial characterization in the rostrocaudal axis of the human anterior olfactory nucleus: Involvement in Parkinson's disease

S Villar-Conde, V Astillero-Lopez… - Frontiers in …, 2022 - frontiersin.org
Hyposmia is one of the prodromal symptoms of Parkinson's disease (PD) and a red flag in
clinical diagnosis. Neuropathologically, this sign correlates with α-synuclein involvement in …

Proteogenomics reveals orthologous alternatively spliced proteoforms in the same human and mouse brain regions with differential abundance in an Alzheimer's …

EMG da Silva, LGC Santos, FS de Oliveira, FCP Freitas… - Cells, 2021 - mdpi.com
Alternative splicing (AS) may increase the number of proteoforms produced by a gene.
Alzheimer's disease (AD) is a neurodegenerative disease with well-characterized AS …

SARS-CoV-2 and Other Respiratory Viruses in Human Olfactory Pathophysiology

SF Wade, AAM Diouara, B Ngom, F Thiam, N Dia - Microorganisms, 2024 - mdpi.com
Acute respiratory viruses (ARVs) are the leading cause of diseases in humans worldwide.
High-risk individuals, including children and the elderly, could potentially develop severe …