Alzheimer's disease (AD) is a complex and progressive neurodegenerative disorder. The
available therapy is limited to the symptomatic treatment and its efficacy remains …

Alzheimer's disease is a multifactorial and fatal neurodegenerative disorder characterized
by decline of cholinergic function, deregulation of other neurotransmitter systems, β-amyloid …

The present article reviews published efforts to study acetylcholinesterase and
butyrylcholinesterase structure and function using computer-based modeling and simulation …

Novel tacrine-related drugs as potential candidates for the treatment of Alzheimer’s disease -
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Quinoline analogs are an important class of N-based heterocyclic compounds, which have
received extensive attention because of their use in medicinal chemistry and organic …

In the current scenario of medicinal chemistry, quinoline plays a pivotal role in the design of
new heterocyclic compounds with several pharmacological properties, so the search for new …

A new series of tacrine-based acetylcholinesterase (AChE) inhibitors 7a–l were designed by
replacing the benzene ring of tacrine with aryl-dihydropyrano [2, 3-c] pyrazole. The poly …

In this work, we describe the preparation of some new Tacrine analogues modified with a
pyranopyrazole moiety. A one-pot multicomponent reaction of 3-methyl-1 H-pyrazol-5 (4H) …

The synthesis, pharmacological analysis and molecular modeling of the readily available
racemic tacrine analogs 21–30, bearing the 7-aryl-9, 10, 11, 12-tetrahydro-7H-benzo [7, 8] …

A series of poly-functionalized tacrine-derived compounds namely 5-amino-2-phenyl-4H-
pyrano [2, 3-b] quinoline-3-carboxylates were designed and synthesized as cholinesterases …