Remyelination, or the restoration of myelin sheaths around axons in the central nervous
system, is a multi-stage repair process that remains a major need for millions of patients with …

Even though several highly effective treatments have been developed for multiple sclerosis
(MS), the underlying pathological mechanisms and drivers of the disease have not been …

Introduction Oligodendrocytes (OLs) are the myelin-forming cells of the central nervous
system (CNS). Although OLs can be differentiated from human-induced pluripotent stem …

Astrocytes are instrumental in maintaining central nervous system (CNS) homeostasis and
responding to injury. A major limitation of studying neurodegenerative diseases like multiple …

Oligodendrocytes originating in the brain and spinal cord as well as in the ventral and dorsal
domains of the neural tube are transcriptomically and functionally distinct. These distinctions …

Regeneration of myelin in the central nervous system is being pursued as a potential
therapeutic approach for multiple sclerosis. Several labs have reported small molecules that …

Brain microphysiological systems (bMPS) recapitulate human brain cellular architecture and
functionality more closely than traditional monolayer cultures and have become increasingly …

Although oligodendrocytes (OLs) synthesize laminin-γ1, the most widely used γ subunit, its
functional significance in the CNS remains unknown. To answer this important question, we …

The inhibition of emopamil binding protein (EBP), a sterol isomerase within the cholesterol
biosynthesis pathway, promotes oligodendrocyte formation, which has been proposed as a …

The capability of human pluripotent stem cells (hPSCs) to self-renew and differentiate into
any cell type has greatly contributed to the advancement of biomedicine. Reporter lines …