The mammalian myosin heavy chain gene family

A Weiss, LA Leinwand - Annual review of cell and …, 1996 - annualreviews.org
▪ Abstract Myosin is a highly conserved, ubiquitous protein found in all eukaryotic cells,
where it provides the motor function for diverse movements such as cytokinesis …

[PDF][PDF] State of the art paper Hyperthyroidism and cardiovascular complications: a narrative review on the basis of pathophysiology

S Ertek, AF Cicero - Archives of Medical Science, 2013 - termedia.pl
Cardiovascular complications are important in hyperthyroidism because of their high
frequency in clinical presentation and increased mortality and morbidity risk. The cause of …

[HTML][HTML] Tissue-specific regulation of the alpha-myosin heavy chain gene promoter in transgenic mice.

A Subramaniam, WK Jones, J Gulick, S Wert… - Journal of Biological …, 1991 - Elsevier
The intergenic region between the mouse alpha-myosin heavy chain (MHC) and beta-MHC
genes was analyzed in terms of its ability to drive gene expression in transgenic mice …

Factors controlling cardiac myosin-isoform shift during hypertrophy and heart failure

MP Gupta - Journal of molecular and cellular cardiology, 2007 - Elsevier
Myosin is a molecular motor, which interacts with actin to convert the energy from ATP
hydrolysis into mechanical work. In cardiac myocytes, two myosin isoforms are expressed …

Transcription factor GATA-4 regulates cardiac muscle-specific expression of the α-myosin heavy-chain gene

JD Molkentin, DV Kalvakolanu… - Molecular and cellular …, 1994 - Am Soc Microbiol
The α-myosin heavy-chain (α-MHC) gene is the major structural protein in the adult rodent
myocardium. Its expression is restricted to the heart by a complex interplay of/ram-acting …

Hyperthyroid heart disease

BM Fadel, S Ellahham, J Lindsay Jr… - Clinical …, 2000 - Wiley Online Library
The heart is an organ sensitive to the action of thyroid hormone, and measurable changes in
cardiac performance are detected with small variations in thyroid hormone serum …

Various hypertrophic stimuli induce distinct phenotypes in cardiomyocytes

MC Schaub, MA Hefti, BA Harder… - Journal of Molecular …, 1997 - Springer
Cardiac hypertrophy is characterized by an increase in cell size in the absence of cell
division and is accompanied by a number of qualitative and quantitative changes in gene …

Altered focal adhesion regulation correlates with cardiomyopathy in mice expressing constitutively active rac1

MA Sussman, S Welch, A Walker… - The Journal of …, 2000 - Am Soc Clin Investig
The ras family of small GTP-binding proteins exerts powerful effects upon cell structure and
function. One member of this family, rac, induces actin cytoskeletal reorganization in …

[HTML][HTML] Progressive maturation in contracting cardiomyocytes derived from human embryonic stem cells: Qualitative effects on electrophysiological responses to …

TG Otsuji, I Minami, Y Kurose, K Yamauchi, M Tada… - Stem cell …, 2010 - Elsevier
The field of drug testing currently needs a new integrated assay system, as accurate as
systems using native tissues, that will allow us to predict arrhythmia risks of candidate drugs …

Pattern of muscle fiber type formation in the pig

L Lefaucheur, F Edom, P Ecolan… - Developmental …, 1995 - Wiley Online Library
The aim of this study was to analyze the temporal sequence of expression of the myosin
isoforms in the populations of muscle fibers in the pig and to bring more information on the …