Cardiovascular impact of drugs used in the treatment of diabetes

CR Triggle, H Ding - Therapeutic advances in chronic …, 2014 - journals.sagepub.com
The International Diabetes Federation predicts that by 2035 10% of the population of the
world will have been diagnosed with diabetes, raising serious concerns over the resulting …

Metabolite profiles of diabetes mellitus and response to intervention in anti-hyperglycemic drugs

Y Liu, D Wang, YP Liu - Frontiers in Endocrinology, 2023 - frontiersin.org
Type 2 diabetes mellitus (T2DM) has become a major health problem, threatening the
quality of life of nearly 500 million patients worldwide. As a typical multifactorial metabolic …

The effect of exenatide (a GLP-1 analogue) and sitagliptin (a DPP-4 inhibitor) on asymmetric dimethylarginine (ADMA) metabolism and selected biomarkers of cardiac …

G Wójcicka, A Pradiuch, E Fornal, A Stachniuk… - Biochemical …, 2023 - Elsevier
Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide (NO)
synthesis, is a risk factor for endothelial dysfunction, a common pathophysiological …

[HTML][HTML] Asymmetric dimethylarginine, a biomarker of cardiovascular complications in diabetes mellitus

H Konya, M Miuchi, K Satani, S Matsutani… - World journal of …, 2015 - ncbi.nlm.nih.gov
Cardiovascular (CV) complications are an essential causal element of prospect in diabetes
mellitus (DM), with carotid atherosclerosis being a common risk factor for prospective crisis …

Asymmetric dimethylarginine: clinical significance and novel therapeutic approaches

D Tousoulis, MK Georgakis… - Current Medicinal …, 2015 - ingentaconnect.com
Asymmetric dimethylarginine (ADMA) is a competitive endogenous inhibitor of nitric oxide
synthase with a key role in the pathophysiology of endothelial dysfunction, in the …

Effect of trelagliptin on vascular endothelial functions and serum adiponectin level in patients with type 2 diabetes: a preliminary single-arm prospective pilot study

S Ida, K Murata, K Betou, C Kobayashi… - Cardiovascular …, 2016 - Springer
Background Trelagliptin, an oral DPP-4 inhibitor, which is administered once per week and
characterized by a long half-life in blood. The effects of trelagliptin on vascular endothelial …

Persons with latent autoimmune diabetes in adults express higher dipeptidyl peptidase-4 activity compared to persons with type 2 and type 1 diabetes

L Duvnjak, K Blaslov, MV Lovrenčić, JK Ćuća - Diabetes research and …, 2016 - Elsevier
Aims We aimed to determine serum dipeptidyl peptidase-4 (DPP-4) activity in a group of
persons with latent autoimmune diabetes in adults (LADA) and to compare it with persons …

DPP-4 inhibitors and cardiovascular disease in type 2 diabetes mellitus. Expectations, observations and perspectives

E Bonora, M Cigolini - Nutrition, Metabolism and Cardiovascular Diseases, 2016 - Elsevier
Aims Cardiovascular disease (CVD) is the greatest burden of type 2 diabetes mellitus
(T2DM) in terms of morbility, mortality and costs for individuals and societies. Therefore, its …

High glucose inhibits ClC-2 chloride channels and attenuates cell migration of rat keratinocytes

F Pan, R Guo, W Cheng, L Chai, W Wang… - Drug Design …, 2015 - Taylor & Francis
Background Accumulating evidence has demonstrated that migration of keratinocytes is
critical to wound epithelialization, and defects of this function result in chronic delayed …

Role of asymmetrical dimethylarginine in diabetic microvascular complications

MR Du, GX Ju, NS Li, JL Jiang - Journal of Cardiovascular …, 2016 - journals.lww.com
Microvascular complications are the leading causes of acquired blindness, end-stage renal
failure, and varieties of neuropathy associated with diabetes. Asymmetric dimethylarginine …