[HTML][HTML] Mitochondrial dynamics, ROS, and cell signaling: a blended overview

V Brillo, L Chieregato, L Leanza, S Muccioli, R Costa - Life, 2021 - mdpi.com
Mitochondria are key intracellular organelles involved not only in the metabolic state of the
cell, but also in several cellular functions, such as proliferation, Calcium signaling, and lipid …

Peptides as pharmacological carriers to the brain: promises, shortcomings and challenges

S Parrasia, I Szabò, M Zoratti… - Molecular …, 2022 - ACS Publications
Central nervous system (CNS) diseases are among the most difficult to treat, mainly
because the vast majority of the drugs fail to cross the blood-brain barrier (BBB) or to reach …

Identification of an ATP-sensitive potassium channel in mitochondria

A Paggio, V Checchetto, A Campo, R Menabò… - Nature, 2019 - nature.com
Mitochondria provide chemical energy for endoergonic reactions in the form of ATP, and
their activity must meet cellular energy requirements, but the mechanisms that link organelle …

[HTML][HTML] Cardamonin inhibits breast cancer growth by repressing HIF-1α-dependent metabolic reprogramming

J Jin, S Qiu, P Wang, X Liang, F Huang, H Wu… - Journal of Experimental …, 2019 - Springer
Background Cardamonin, a chalcone isolated from Alpiniae katsumadai, has anti-
inflammatory and anti-tumor activities. However, the molecular mechanism by which …

[HTML][HTML] Potassium channels as a target for cancer therapy: Current perspectives

L Zúñiga, A Cayo, W González, C Vilos… - OncoTargets and …, 2022 - ncbi.nlm.nih.gov
Potassium (K+) channels are highly regulated membrane proteins that control the potassium
ion flux and respond to different cellular stimuli. These ion channels are grouped into three …

[HTML][HTML] Coordinate β-adrenergic inhibition of mitochondrial activity and angiogenesis arrest tumor growth

C Nuevo-Tapioles, F Santacatterina… - Nature …, 2020 - nature.com
Mitochondrial metabolism has emerged as a promising target against the mechanisms of
tumor growth. Herein, we have screened an FDA-approved library to identify drugs that …

[HTML][HTML] Application prospects of triphenylphosphine-based mitochondria-targeted cancer therapy

X Cheng, D Feng, J Lv, X Cui, Y Wang, Q Wang… - Cancers, 2023 - mdpi.com
Simple Summary Although there are various treatments for tumors, chemotherapy is still one
of the most dominant and irreplaceable treatment modalities nowadays. Unfortunately …

Cinnamon cassia oil chitosan nanoparticles: Physicochemical properties and anti-breast cancer activity

X Xu, Q Li, W Dong, G Zhao, Y Lu, X Huang… - International Journal of …, 2023 - Elsevier
The aim of this study was to prepare Cinnamomum cassia essential oil (CEO) impregnated
chitosan nanoparticles (CS-CEO) and assess its pharmacological activity against breast …

Mitochondria as a novel target for cancer chemoprevention: emergence of mitochondrial-targeting agents

M Huang, CR Myers, Y Wang, M You - Cancer Prevention Research, 2021 - AACR
Cancer chemoprevention is the most effective approach to control cancer in the population.
Despite significant progress, chemoprevention has not been widely adopted because …

[HTML][HTML] Mitochondrial metal ion transport in cell metabolism and disease

X Wang, P An, Z Gu, Y Luo, J Luo - International journal of molecular …, 2021 - mdpi.com
Mitochondria are vital to life and provide biological energy for other organelles and cell
physiological processes. On the mitochondrial double layer membrane, there are a variety of …