The neurotransmitter acetylcholine (ACh) can regulate neuronal excitability by acting on the
cys-loop cation-conducting ligand-gated nicotinic ACh receptor (nAChR) channels. These …

Introduction The prevalence of tobacco use in the population with schizophrenia is
enormously high. Moreover, nicotine dependence is found to be associated with symptom …

Purpose of review: To provide an overview of the underlying neurobiology of tobacco
smoking in schizophrenia, and implications for treatment of this comorbidity. Recent findings …

The α7 nicotinic acetylcholine receptor gene (CHRNA7) is linked to schizophrenia. A partial
duplication of CHRNA7 (CHRFAM7A) is found in humans on 15q13–14. Exon 6 of …

Schizophrenic patients have a high rate of smoking and cognitive deficits which may be
related to a decreased number or responsiveness of nicotinic receptors in their brains …

Substance use disorders are chronic, relapsing, and harmful conditions characterized by
executive dysfunction. While there are currently no approved pharmacotherapy options for …

Background: Cholinergic dysfunction is increasingly assumed to be involved in the
pathophysiology of schizophrenia. Short-latency afferent inhibition (SAI) is a transcranial …

Schizophrenia is associated with by severe disruptions in thought, cognition, emotion, and
behavior. Patients show a marked increase in rates of smoking and nicotine dependence …

Despite the proven association between smoking and high rates of medical morbidity and
reduced life expectancy in people with severe mental disorders (SMD), their smoking rates …

Acetylcholine (ACh) signaling is critical for central nervous function and is known to be
abnormal in schizophrenia (SZ), a chronic neuropsychiatric disorder in which cognitive …